Сравнение
CJC-1295 vs. Mod GRF (1-29)
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Рост
Рост
Номер CAS
нет данных
863288-34-0
Молекулярная масса
3647.3 g/mol
3367.9 g/mol
Период полувыведения
144 h
0.5 h
Последовательность
YADAIFTNSYRKVLGQLSARKLLQDIMSR-DACTyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2Механизм действия
CJC-1295
Synthetic analogue of growth-hormone-releasing hormone (GHRH), modified for extended half-life via a Drug Affinity Complex (DAC) binding to albumin. Acts on the pituitary GHRH receptor and stimulates endogenous growth-hormone release.
Mod GRF (1-29)
Synthetic analogue of the first 29 amino acids of growth-hormone-releasing hormone (GHRH 1-29). Four amino-acid substitutions (D-Ala at position 2, Gln at 8, Ala at 15, Leu at 27) are intended to slow degradation by dipeptidyl peptidase-IV and increase enzymatic stability relative to native GHRH. Like the native hormone and sermorelin, it binds the GHRH receptor on somatotroph cells of the anterior pituitary; mechanistically this is expected to stimulate endogenous growth-hormone release. Unlike the DAC-conjugated CJC-1295 variant, it lacks albumin binding, so its duration of action remains short.
Доказательная база
Наивысшая доказательность
Исследование на людях
Исследование на людях
Исследования
4
4
из них на людях
3
4
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
3
0
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between CJC-1295 and Mod GRF (1-29)?
- CJC-1295 is classified as "Рост", while Mod GRF (1-29) is classified as "Рост". CJC-1295: Long-acting synthetic GHRH analogue modified for albumin binding (DAC). Stimulates endogenous growth-hormone release. Pharmacodynamic effect established in small human studies; clinical endpoint trials are missing. Mod GRF (1-29): Tetrasubstituted synthetic analogue of GHRH(1-29), traded on the grey market as "CJC-1295 without DAC". Closely related to sermorelin (GHRH 1-29); a short-acting growth-hormone-releasing-hormone analogue often combined with a GHRP/ghrelin mimetic. Not approved as a medicinal product. Direct human trials of this exact analogue are essentially absent; the factual basis relies on related GHRH(1-29) analogues. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, CJC-1295 or Mod GRF (1-29)?
- The highest available evidence level is "Исследование на людях" for CJC-1295 and "Исследование на людях" for Mod GRF (1-29). A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of CJC-1295 and Mod GRF (1-29) in Germany and the United States?
- Германия: CJC-1295 — Не одобрено, Mod GRF (1-29) — Не одобрено. США: CJC-1295 — Только для исследований, Mod GRF (1-29) — Только для исследований. These are factual summaries with source and review date on the individual pages.