Сравнение
Glepaglutide vs. Melanotan II
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
нет данных
121062-08-6
Молекулярная масса
нет данных
1024.18 g/mol
Период полувыведения
нет данных
1 h
Последовательность
нет данных
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Механизм действия
Glepaglutide
As a GLP-2 receptor agonist, glepaglutide has a trophic effect on the intestinal mucosa, enlarging the absorptive surface and thereby improving intestinal uptake of nutrients and fluid.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
1
9
из них на людях
1
5
Зафиксированные эффекты
2
4
Открытые противоречия
0
1
Задокументированные нежелательные явления
1
6
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Glepaglutide and Melanotan II?
- Glepaglutide is classified as "Исследования (прочее)", while Melanotan II is classified as "Исследования (прочее)". Glepaglutide: Glepaglutide is a long-acting GLP-2 analogue (Zealand Pharma) intended to reduce the need for parenteral support in short bowel syndrome. Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Glepaglutide or Melanotan II?
- The highest available evidence level is "РКИ на людях" for Glepaglutide and "Исследование на людях" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Glepaglutide and Melanotan II in Germany and the United States?
- Германия: Glepaglutide — Не одобрено, Melanotan II — Не одобрено. США: Glepaglutide — Не одобрено, Melanotan II — Не одобрено. These are factual summaries with source and review date on the individual pages.