Сравнение
Gonadorelin vs. Sincalide
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
33515-09-2
25126-32-3
Молекулярная масса
1182.29 g/mol
1143.29 g/mol
Период полувыведения
0.1 h
нет данных
Последовательность
pGlu-His-Trp-Ser-Tyr-Gly-Leu-Arg-Pro-Gly-NH2Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2Механизм действия
Gonadorelin
Gonadorelin acts as an agonist at the GnRH receptor on the gonadotroph cells of the pituitary and triggers release of the gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH). The temporal pattern of receptor exposure is decisive: pulsatile administration mimics the natural hypothalamic secretory rhythm and sustains LH/FSH release, whereas continuous exposure leads to receptor internalisation and desensitisation with subsequent paradoxical suppression of gonadotropins. The latter principle is exploited therapeutically by longer-acting GnRH agonists.
Sincalide
Sincalide activates CCK receptors, triggering gallbladder contraction and pancreatic enzyme secretion. This effect is used diagnostically to measure the gallbladder ejection fraction (e.g. in HIDA scintigraphy).
Доказательная база
Наивысшая доказательность
Исследование на людях
Исследование на людях
Исследования
4
0
из них на людях
4
0
Зафиксированные эффекты
4
1
Открытые противоречия
1
0
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Gonadorelin and Sincalide?
- Gonadorelin is classified as "Исследования (прочее)", while Sincalide is classified as "Исследования (прочее)". Gonadorelin: Gonadorelin is the synthetic decapeptide with an amino-acid sequence identical to endogenous gonadotropin-releasing hormone (GnRH/LHRH). Historically approved in several countries for diagnostic testing of pituitary function and for fertility indications (pump systems). A defining feature is the opposite effect of pulsatile versus continuous administration: pulsatile stimulates, continuous leads to receptor desensitisation. Sincalide: Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbladder contraction for diagnostic imaging. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Gonadorelin or Sincalide?
- The highest available evidence level is "Исследование на людях" for Gonadorelin and "Исследование на людях" for Sincalide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Gonadorelin and Sincalide in Germany and the United States?
- Германия: Gonadorelin — Рецептурный, Sincalide — Неясно. США: Gonadorelin — Рецептурный, Sincalide — Рецептурный. These are factual summaries with source and review date on the individual pages.