Сравнение

Histrelin vs. Triptorelin

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

220810-26-4

57773-63-4

Молекулярная масса

1323.52 g/mol

1311.45 g/mol

Период полувыведения

нет данных

3 h

Последовательность

нет данных

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-Gly-NH2

Механизм действия

Histrelin

Continuous GnRH-agonist stimulation downregulates and desensitises the pituitary GnRH receptors — after the initial rise, LH, FSH and the sex hormones fall persistently.

Triptorelin

Triptorelin binds with high affinity to the GnRH receptor in the pituitary. After initial stimulation of LH and FSH secretion (flare phase, about 1-2 weeks), receptor desensitisation follows with consecutive gonadotropin suppression. This results in a reversible chemical castration: in men testosterone, in women oestrogen suppression to the postmenopausal range.

Доказательная база

Наивысшая доказательность

РКИ на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Histrelin	Triptorelin
Германия	Рецептурный	Рецептурный
США	Рецептурный	Рецептурный

Полные записи

Frequently asked questions

What is the difference between Histrelin and Triptorelin?: Histrelin is classified as "Исследования (прочее)", while Triptorelin is classified as "Исследования (прочее)". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Histrelin or Triptorelin?: The highest available evidence level is "РКИ на людях" for Histrelin and "РКИ на людях" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Histrelin and Triptorelin in Germany and the United States?: Германия: Histrelin — Рецептурный, Triptorelin — Рецептурный. США: Histrelin — Рецептурный, Triptorelin — Рецептурный. These are factual summaries with source and review date on the individual pages.

Country

Histrelin

Triptorelin

Германия

Рецептурный

США

Рецептурный

Frequently asked questions

What is the difference between Histrelin and Triptorelin?

Histrelin is classified as "Исследования (прочее)", while Triptorelin is classified as "Исследования (прочее)". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Triptorelin: Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Histrelin or Triptorelin?

The highest available evidence level is "РКИ на людях" for Histrelin and "РКИ на людях" for Triptorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Histrelin and Triptorelin in Germany and the United States?

Германия: Histrelin — Рецептурный, Triptorelin — Рецептурный. США: Histrelin — Рецептурный, Triptorelin — Рецептурный. These are factual summaries with source and review date on the individual pages.