Сравнение
Mazdutide vs. Petrelintide
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
2259884-03-0
нет данных
Молекулярная масса
4790 g/mol
нет данных
Период полувыведения
132 h
нет данных
Последовательность
synthetisches Oxyntomodulin-Analogon (39 Aminosäuren) mit Fettsäureseitenketteнет данных
Механизм действия
Mazdutide
Mazdutide is a dual agonist at the GLP-1 and glucagon receptors and is structurally derived from the gut hormone oxyntomodulin. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secretion at elevated blood glucose, and modulation of appetite and gastric emptying. The glucagon component can influence energy expenditure and hepatic lipid and glucose metabolism. A fatty-acid side chain enables albumin binding and the weekly administration interval.
Petrelintide
As an amylin analogue, petrelintide acts through amylin receptors, promoting satiety and slowed gastric emptying — a satiety pathway independent of the GLP-1 axis.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
4
1
из них на людях
4
1
Зафиксированные эффекты
4
2
Открытые противоречия
0
0
Задокументированные нежелательные явления
0
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Mazdutide and Petrelintide?
- Mazdutide is classified as "Метаболизм", while Petrelintide is classified as "Метаболизм". Mazdutide: Synthetic oxyntomodulin analogue that simultaneously activates the GLP-1 and glucagon receptors (dual agonist). Developed by Innovent Biologics and Eli Lilly. In China the NMPA approved mazdutide on 27 June 2025 for chronic weight management; a further filing for type 2 diabetes is under review in China. Outside China the substance remains in clinical development. Petrelintide: Petrelintide is a long-acting amylin analogue (Zealand Pharma, with Roche) for once-weekly subcutaneous use — developed for weight management with a focus on strong tolerability. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Mazdutide or Petrelintide?
- The highest available evidence level is "РКИ на людях" for Mazdutide and "РКИ на людях" for Petrelintide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Mazdutide and Petrelintide in Germany and the United States?
- Германия: Mazdutide — Только для исследований, Petrelintide — Не одобрено. США: Mazdutide — Только для исследований, Petrelintide — Не одобрено. These are factual summaries with source and review date on the individual pages.