Сравнение
Melanotan II vs. Terlipressin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
121062-08-6
14636-12-5
Молекулярная масса
1024.18 g/mol
1227.37 g/mol
Период полувыведения
1 h
нет данных
Последовательность
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2нет данных
Механизм действия
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Terlipressin
Terlipressin is slowly converted in the body to lysine-vasopressin by cleavage of the three N-terminal glycyl residues (reservoir effect) and activates V1 receptors. The splanchnic vasoconstriction improves renal perfusion in hepatorenal syndrome.
Доказательная база
Наивысшая доказательность
Исследование на людях
РКИ на людях
Исследования
9
1
из них на людях
5
1
Зафиксированные эффекты
4
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
6
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Melanotan II and Terlipressin?
- Melanotan II is classified as "Исследования (прочее)", while Terlipressin is classified as "Исследования (прочее)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Terlipressin: Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is approved for hepatorenal syndrome (FDA 2022, Terlivaz). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Terlipressin?
- The highest available evidence level is "Исследование на людях" for Melanotan II and "РКИ на людях" for Terlipressin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Terlipressin in Germany and the United States?
- Германия: Melanotan II — Не одобрено, Terlipressin — Рецептурный. США: Melanotan II — Не одобрено, Terlipressin — Рецептурный. These are factual summaries with source and review date on the individual pages.