Сравнение
Octreotide vs. Selank
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
83150-76-9
129954-34-3
Молекулярная масса
1019.24 g/mol
751.85 g/mol
Период полувыведения
1.7 h
0.3 h
Последовательность
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)Thr-Lys-Pro-Arg-Pro-Gly-ProМеханизм действия
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
5
4
из них на людях
4
2
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Octreotide and Selank?
- Octreotide is classified as "Исследования (прочее)", while Selank is classified as "Исследования (прочее)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Selank?
- The highest available evidence level is "РКИ на людях" for Octreotide and "Исследование на людях" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Selank in Germany and the United States?
- Германия: Octreotide — Рецептурный, Selank — Не одобрено. США: Octreotide — Рецептурный, Selank — Не одобрено. These are factual summaries with source and review date on the individual pages.