Сравнение
Sermorelin vs. Tesamorelin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Рост
Рост
Номер CAS
86168-78-7
901758-09-6
Молекулярная масса
3358 g/mol
5135.83 g/mol
Период полувыведения
0.2 h
0.4 h
Последовательность
YADAIFTNSYRKVLGQLSARKLLQDIMSRtrans-3-hexenoyl-Tyr-Ala-Asp-Ala-Ile-Phe-Thr-Asn-Ser-Tyr-Arg-Lys-Val-Leu-Gly-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Met-Ser-Arg-Gln-Gln-Gly-Glu-Ser-Asn-Gln-Glu-Arg-Gly-Ala-Arg-Ala-Arg-Leu-NH2Механизм действия
Sermorelin
Synthetic analogue of the first 29 amino acids of human growth-hormone-releasing hormone (GHRH). Stimulates pulsatile endogenous growth-hormone secretion from the pituitary via the GHRH receptor. Very short plasma half-life — pharmacodynamic effect lasts several hours nevertheless.
Tesamorelin
Tesamorelin is an N-terminally modified 44-amino-acid version of human GHRH(1-44). A 3-hexenoyl modification protects against rapid dipeptidyl-peptidase-IV cleavage. Binding to the pituitary GHRH receptor stimulates endogenous pulsatile growth-hormone secretion and consequently hepatic IGF-1 production.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
4
из них на людях
3
4
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
3
2
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Sermorelin and Tesamorelin?
- Sermorelin is classified as "Рост", while Tesamorelin is classified as "Рост". Sermorelin: Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate. Tesamorelin: Stabilised GHRH analog (growth-hormone-releasing hormone). FDA-approved in 2010 as Egrifta for reduction of abdominal lipohypertrophy in HIV-associated lipodystrophy. Not approved for the general population. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Sermorelin or Tesamorelin?
- The highest available evidence level is "РКИ на людях" for Sermorelin and "РКИ на людях" for Tesamorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Sermorelin and Tesamorelin in Germany and the United States?
- Германия: Sermorelin — Не одобрено, Tesamorelin — Не одобрено. США: Sermorelin — Только для исследований, Tesamorelin — Рецептурный. These are factual summaries with source and review date on the individual pages.