Angiogenesis
Formation of new blood vessels from existing ones. Mechanistically central to wound healing and tissue repair — but also relevant to tumour biology, which is why proliferative effects must be considered.
Peptides on this topic
3 пептидов с исследованиями по этой темеSynthetic pentadecapeptide (15 amino acids) derived from a sequence of a gastric-juice protein. Studied predominantly in animal models on healing and protective processes — controlled human trials are rare and limited in scope.
- Модель на животныхAccelerated healing of tendon injuries
- Модель на животныхProtection of the gastric mucosa
Synthetic fragment of the endogenous protein Thymosin Beta-4, specifically the actin-binding sequence. Preclinical models investigate effects on cell migration, neovascularisation and wound healing — robust human data are absent.
- Модель на животныхAccelerated wound and tissue healing
- In vitroPromotion of angiogenesis via actin binding
Thymosin Beta-4 (Tβ4) is an endogenous 43-amino-acid peptide regarded as the principal intracellular actin-sequestering factor, involved in cell migration, neovascularisation and tissue regeneration. It has been studied in dry eye, corneal and wound healing, and cardiac repair (RegeneRx programmes, RGN-259). Thymosin Beta-4 is NOT an approved drug; robust human efficacy data are limited. The grey-market TB-500 is a synthetic fragment/analogue and is distinct from it.
- Исследование на людяхImprovement of signs and symptoms in severe dry eye disease
- Модель на животныхPromotion of dermal wound healing