Anti-aging
Umbrella term for interventions against visible and biological aging processes. Endpoints range from skin parameters (wrinkles, hydration) to body composition and surrogate markers like IGF-1. Heterogeneous evidence, many anecdotal claims.
Peptides on this topic
10 пептидов с исследованиями по этой темеSynthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking action of botulinum toxin, but with substantially lower potency and without intramuscular effect. EU-compliant as a cosmetic ingredient (CosIng), not approved as a medicine.
- Исследование на людяхVisual reduction of wrinkle depth in dynamic areas (forehead, periorbital) reported in industry-sponsored cosmetic studies
Long-acting synthetic GHRH analogue modified for albumin binding (DAC). Stimulates endogenous growth-hormone release. Pharmacodynamic effect established in small human studies; clinical endpoint trials are missing.
- Исследование на людяхIncrease in growth-hormone level after administration
- Исследование на людяхElevated IGF-1 level
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US.
- In vitroActivation of telomerase in human somatic cells reported in an in-vitro study by the Khavinson group
- Модель на животныхLifespan extension and altered tumour incidence in aged mice reported in Russian animal experiments
Synthetic peptide with D-Retro-Inverso structure (all amino acids as D-form, sequence reversed), developed in 2017 as an experimental senolytic candidate. Goal: selective apoptosis of senescent cells via disruption of the FOXO4-p53 interaction. So far evaluated exclusively preclinically.
- Модель на животныхSelective elimination of senescent cells in multiple tissues of old and chemotherapy-treated mice documented
- Модель на животныхImprovement of marker endpoints (hair growth, renal function, running endurance) reported in the original mouse study after multi-week treatment
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU.
- In vitroPromotion of collagen synthesis in fibroblast cultures
- Исследование на людяхChanges in cutaneous parameters under topical application
Humanin is a 24-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within the 16S rRNA region (gene MT-RNR2) of mitochondrial DNA. It is considered the founding member of the MDP family and was discovered in 2001 by the Hashimoto/Nishimoto group while searching for neuroprotective factors in the brain of an Alzheimer's patient. In basic research (including the laboratory of Pinchas Cohen) humanin is described as a cytoprotective, anti-apoptotic peptide and is studied in the contexts of Alzheimer's/neuroprotection, metabolism/insulin action and aging. The evidence comes almost entirely from cell and animal models and from observations of endogenous levels in humans; controlled human trials of exogenous humanin as a therapeutic are lacking. It is not approved as a medicine anywhere and is traded on the grey market as a research chemical.
- In vitroProtection of neurons from cell death induced by Alzheimer's-associated proteins (mutant APP, presenilin) and amyloid-beta, in cell culture
Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine.
- In vitroStimulation of collagen synthesis in human dermal fibroblast cultures reproducibly documented
MOTS-c is a 16-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within the 12S rRNA region of mitochondrial DNA. In basic research (including the laboratories of Changhan Lee and Pinchas Cohen) it is described as a regulator of metabolic homeostasis and an activator of the AMPK pathway, and is sometimes discussed as an 'exercise mimetic'. The evidence comes almost entirely from cell and animal models; controlled human trials of MOTS-c as a therapeutic are lacking. It is not approved as a medicine anywhere and is traded on the grey market as a research chemical.
- Модель на животныхActivation of the AMPK pathway and improved glucose handling in cell and mouse models
Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA-approved as Geref Diagnostic, now withdrawn in many markets — compounding and research use dominate.
- РКИ на людяхStimulation of growth-hormone release
- Исследование на людяхUse as a diagnostic provocation test for GH deficiency
Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapeptide-3) but with two additional C-terminal amino acids. Manufacturer marketing positions SNAP-8 as an 'improved' Argireline variant.
- Исследование на людяхVisual reduction of expression wrinkles documented in manufacturer-sponsored studies on various skin areas