Precocious puberty
Central precocious puberty in children. GnRH analogs (triptorelin) delay the pituitary LH/FSH axis — an approved paediatric indication.
Peptides on this topic
3 пептидов с исследованиями по этой темеHistrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas).
- РКИ на людяхSuppresses sex hormones via a yearly implant — in precocious puberty and prostate cancer.
- Исследование на людяхImplant form (once a year) instead of regular injections.
Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation.
- РКИ на людяхWith continuous exposure, LH and FSH are suppressed, with subsequent lowering of sex steroids.
- РКИ на людяхIn randomized endometriosis studies, leuprorelin was associated with greater reduction of pain parameters versus placebo.
Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty.
- РКИ на людяхSuppression of testosterone into the castration range (<50 ng/dL) within 4 weeks in men with prostate cancer documented
- РКИ на людяхReduction of endometriosis pain and lesion size demonstrated versus placebo in randomised trials