Confronto
DSIP vs. Teduglutid
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
62568-57-4
197922-42-2
Peso molecolare
848.81 g/mol
3752.13 g/mol
Emivita
0.1 h
nessun dato
Sequenza
Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glunessun dato
Meccanismo d'azione
DSIP
DSIP was described in 1977 by the Schoenenberger-Monnier group in Basel as a blood-borne substance reported to induce EEG changes similar to delta sleep in animal models. The exact mechanism remains undefined to this day: no defined receptor, proposed modulation of opioid, GABAergic and glutamatergic systems. Most mechanistic findings stem from preclinical studies of the 1980s and 1990s and were later subjected to contested replication attempts.
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Base di evidenze
Evidenza più alta
Studio sull'uomo
RCT sull'uomo
Studi
4
2
di cui sull'uomo
1
2
Effetti registrati
3
2
Contraddizioni aperte
1
0
Eventi avversi documentati
1
2
Stato legale
Voci complete
Frequently asked questions
- What is the difference between DSIP and Teduglutid?
- DSIP is classified as "Ricerca (altro)", while Teduglutid is classified as "Ricerca (altro)". DSIP: Synthetic nonapeptide isolated in 1977 by Guido Monnier and Marcel Schoenenberger from the blood of rabbits in delta sleep. Despite the name, the role in sleep regulation is contested and not confirmed by Western RCTs in larger populations. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, DSIP or Teduglutid?
- The highest available evidence level is "Studio sull'uomo" for DSIP and "RCT sull'uomo" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of DSIP and Teduglutid in Germany and the United States?
- Germania: DSIP — Non approvato, Teduglutid — Su prescrizione. Stati Uniti: DSIP — Non approvato, Teduglutid — Su prescrizione. These are factual summaries with source and review date on the individual pages.