Peptidi A–Z
Tutto ciò che devi sapere sui peptidi — contestualizzato scientificamente.
Identità, meccanismo, base di evidenze, stato legale, rischi, confronti — per ogni peptide in una sola voce. Con il livello di evidenza visibile e le fonti sotto ogni affermazione. Non è una raccomandazione d'uso.
87
Peptidi registrati
274
Studi aggregati
14
Paesi con stato legale
Evidence distribution
263 observations
Da dove comincio?
Tre vie d'accesso — a seconda di ciò che ti serve ora
Nuovo all'argomento
Capire di cosa si tratta
Cosa sono i peptidi, come funzionano i livelli di evidenza e cosa questo sito deliberatamente non è — in circa 6 minuti.
Inizia qui →Un peptide specifico
Cercare un peptide particolare
Cerca per nome, sinonimo o area di applicazione e arriva direttamente alla voce completa.
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Cosa troverai
Sei vie nel mondo dei peptidi
01
Identità
Schede per ogni peptide
Identità chimica, classe, sinonimi, sequenza, peso molecolare — in modo compatto all'inizio di ogni voce.
02
Meccanismo
Come agisce a livello biologico
Meccanismo d'azione spiegato in modo neutrale, termini del glossario collegati automaticamente.
03
Studi
Evidenze trasparenti
Ogni affermazione con un livello di evidenza visibile — dall'RCT sull'uomo all'aneddotico. Filtrabile.
04
Stato legale
Paese per paese
Approvato, ricerca, restrizione, divieto — con fonte e data.
05
Confronto
Due peptidi affiancati
Identità, evidenze, stato legale, eventi avversi — direttamente confrontabili.
06
Glossario
Termini tecnici, in modo chiaro
Passa il cursore su un termine e la definizione appare nel testo.
Distribuzione delle evidenze
Cosa documenta questa piattaforma
Aggregato su tutti i peptidi catalogati. Ogni osservazione documentata porta il suo livello di evidenza visibile — dall'RCT sull'uomo fino all'aneddotico. I livelli più deboli restano deliberatamente visibili.
263 osservazioni documentate in totale
RCT sull'uomo113
43.0% · Solo RCT sull'uomo nel lessico →
Studio sull'uomo82
31.2% · Solo Studio sull'uomo nel lessico →
Modello animale32
12.2% · Solo Modello animale nel lessico →
In vitro18
6.8% · Solo In vitro nel lessico →
Preclinico6
2.3% · Solo Preclinico nel lessico →
Aneddotico5
1.9% · Solo Aneddotico nel lessico →
Teorico7
2.7% · Solo Teorico nel lessico →
Successi comprovati
Ciò che la ricerca mostra in positivo
Non tutto è clamore — questi effetti sono dimostrati in studi controllati. I risultati più solidi, riportati in modo neutrale e collegati.
Semaglutide
−20% di eventi cardiovascolari maggiori
SELECT · RCT sull'uomo
Tirzepatide
oltre −20% di peso corporeo
SURMOUNT · RCT sull'uomo
Efinopegdutide
−72,7% di grasso epatico (vs. −42% con semaglutide)
RCT di fase 2
Tesamorelin
−15% di grasso addominale viscerale
RCT di fase 3
Lanreotide
sopravvivenza libera da progressione prolungata (NET)
CLARINET · RCT sull'uomo
GHK-Cu
stimolazione del collagene nel 70% dei volontari — più della vitamina C/acido retinoico
studio sull'uomo · topico
Aggiornamenti
Rivisto di recente
Le cinque voci di peptidi aggiornate più di recente. Cronologia completa nel feed RSS.
Famiglie
Per area di applicazione
In primo piano
RCT sull'uomoRicerca (altro) · 5 studies
Bremelanotide
Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual desire disorder (HSDD) in pre-menopausal women..
Apri voce →Quick facts
CAS189691-06-3
SequenceAc-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-OH
MW1025.18 g/mol
t½2.7 h
Effects3
Conflicts1
Registro delle voci
Tutti i peptidi catalogati
Abaloparatid
RCT sull'uomoRicerca (altro) · 3960.6 g/mol · t½ 1.7h
Abaloparatide is a synthetic 34-amino-acid analogue of parathyroid hormone-related protein (PTHrP 1-34). It is regulatory-approved and studi…
Afamelanotide
RCT sull'uomoRicerca (altro) · 1646.87 g/mol · t½ 12h
Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melanocortin-1 r…
Amycretin
RCT sull'uomoMetabolico
Amycretin is a unimolecular GLP-1 and amylin receptor agonist from Novo Nordisk — in development both as a once-weekly subcutaneous and a on…
AOD-9604
RCT sull'uomoCrescita · 1815.09 g/mol · t½ 0.4h
Synthetic 16-amino-acid peptide corresponding to the C-terminal fragment of human growth hormone (hGH 176-191). Originally developed by Meta…
Argireline
Studio sull'uomoCosmetico · 888.99 g/mol
Synthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking a…
BPC-157
Modello animaleGuarigione · 1419.5 g/mol · t½ 4h
Synthetic pentadecapeptide (15 amino acids) derived from a sequence of a gastric-juice protein. Studied predominantly in animal models on he…
Bremelanotide
RCT sull'uomoRicerca (altro) · 1025.18 g/mol · t½ 2.7h
Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoactive sexual…
Buserelin
RCT sull'uomoRicerca (altro) · 1239.42 g/mol
Buserelin is a synthetic GnRH agonist (including as a nasal spray). It is used in endometriosis, hormone-dependent prostate cancer and assis…
Cagrilintide
RCT sull'uomoMetabolico · 4253.7 g/mol · t½ 168h
Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and type 2 diabe…
CagriSema
RCT sull'uomoMetabolico
CagriSema is a fixed-dose combination of the amylin analogue cagrilintide and the GLP-1 agonist semaglutide (Novo Nordisk), in late-stage de…
Calcitonin (Lachs)
RCT sull'uomoRicerca (altro) · 3431.85 g/mol · t½ 1h
Salmon calcitonin is a synthetically produced 32-amino-acid peptide hormone that corresponds to the body's own calcitonin but exhibits highe…
Carbetocin
RCT sull'uomoRicerca (altro) · t½ 0.67h
Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Appr…
Cerebrolysin
RCT sull'uomoRicerca (altro)
Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acid…
Cetrorelix
RCT sull'uomoRicerca (altro) · 1431.06 g/mol
Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during …
CJC-1295
Studio sull'uomoCrescita · 3647.3 g/mol · t½ 144h
Long-acting synthetic GHRH analogue modified for albumin binding (DAC). Stimulates endogenous growth-hormone release. Pharmacodynamic effect…
Degarelix
RCT sull'uomoRicerca (altro) · 1632.3 g/mol · t½ 1320h
Degarelix (trade name Firmagon) is a synthetic decapeptide and a gonadotropin-releasing hormone (GnRH) receptor antagonist. Unlike GnRH agon…
Desmopressin
RCT sull'uomoRicerca (altro) · 1069.2 g/mol · t½ 3h
Desmopressin (DDAVP) is a synthetic analogue of the endogenous hormone vasopressin (antidiuretic hormone, ADH). Deamination of the first ami…
DSIP
Studio sull'uomoRicerca (altro) · 848.81 g/mol · t½ 0.1h
Synthetic nonapeptide isolated in 1977 by Guido Monnier and Marcel Schoenenberger from the blood of rabbits in delta sleep. Despite the name…
Dulaglutide
RCT sull'uomoMetabolico · 59670 g/mol · t½ 110h
GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fragment. FDA…
Ecnoglutide
RCT sull'uomoMetabolico · t½ 144h
Ecnoglutide (XW003) is a long-acting, cAMP-signalling-biased GLP-1 analogue from Sciwind Biosciences. Derived from GLP-1(7-37) with an alani…
Efinopegdutide
RCT sull'uomoMetabolico · t½ 115h
Efinopegdutide (MK-6024, formerly JNJ-64565111 / HM12525A) is a once-weekly dual agonist at the GLP-1 and glucagon receptors, developed by H…
Elamipretide
RCT sull'uomoRicerca (altro) · 639.8 g/mol
Elamipretide (SS-31, MTP-131, formerly Bendavia) is a synthetic, mitochondria-targeting tetrapeptide (sequence D-Arg-Dmt-Lys-Phe-NH2) that b…
Eloralintide
RCT sull'uomoMetabolico
Eloralintide is a selective, long-acting amylin receptor agonist from Eli Lilly for once-weekly subcutaneous use — under investigation for o…
Enfuvirtid
RCT sull'uomoRicerca (altro) · 4491.88 g/mol
Enfuvirtide is a synthetic 36-amino-acid peptide and the first HIV-1 fusion inhibitor. It binds the HR1 region of the viral envelope protein…
Epitalon
Studio sull'uomoRicerca (altro) · 390.35 g/mol · t½ 0.3h
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Rus…
Exenatide
RCT sull'uomoMetabolico · 4186.6 g/mol · t½ 2.4h
Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist,…
Follistatin (FST)
Studio sull'uomoCrescita · 35000 g/mol
Follistatin is an endogenous glycosylated binding protein (~35 kDa, considerably larger than typical peptides) that binds and neutralises me…
FOXO4-DRI
Modello animaleRicerca (altro) · 3735 g/mol · t½ 0.5h
Synthetic peptide with D-Retro-Inverso structure (all amino acids as D-form, sequence reversed), developed in 2017 as an experimental senoly…
Ganirelix
RCT sull'uomoRicerca (altro) · 1570.3 g/mol
Ganirelix is a synthetic decapeptide and GnRH antagonist. In assisted reproduction (IVF) it prevents the premature LH surge during controlle…
GHK-Cu
Studio sull'uomoCosmetico · 340.4 g/mol
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen …
GHRP-2
Studio sull'uomoCrescita · 817.93 g/mol · t½ 0.5h
Synthetic hexapeptide of the GH secretagogue family. Approved in Japan as GHRP Kaken as a diagnostic test for GH deficiency. Not available a…
GHRP-6
Studio sull'uomoCrescita · 873.02 g/mol · t½ 0.4h
Synthetic hexapeptide that founded the class of growth-hormone-releasing peptides (GHRPs). Cyril Bowers identified GHRP-6 in the late 1970s …
Glepaglutide
RCT sull'uomoRicerca (altro)
Glepaglutide is a long-acting GLP-2 analogue (Zealand Pharma) intended to reduce the need for parenteral support in short bowel syndrome.…
Glucagon
RCT sull'uomoMetabolico · 3483 g/mol · t½ 0.13h
Glucagon is a 29-amino-acid pancreatic hormone produced by the alpha cells of the islets of Langerhans. It is the physiological counterpart …
Gonadorelin
Studio sull'uomoRicerca (altro) · 1182.29 g/mol · t½ 0.1h
Gonadorelin is the synthetic decapeptide with an amino-acid sequence identical to endogenous gonadotropin-releasing hormone (GnRH/LHRH). His…
Goserelin
RCT sull'uomoRicerca (altro) · 1269.43 g/mol · t½ 4.2h
Goserelin is a synthetic decapeptide and an agonist of gonadotropin-releasing hormone (GnRH). The medical literature describes it as a hormo…
Hexarelin
Studio sull'uomoCrescita · 887.05 g/mol · t½ 0.9h
Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH def…
Histrelin
RCT sull'uomoRicerca (altro) · 1323.52 g/mol
Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin L…
Humanin
Studio sull'uomoRicerca (altro) · 2687.27 g/mol
Humanin is a 24-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within the 16S r…
Icatibant
RCT sull'uomoRicerca (altro) · 1304.52 g/mol
Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of heredi…
IGF-1 LR3
Modello animaleCrescita · 9117.6 g/mol · t½ 21h
Synthetic analogue of insulin-like growth factor 1 (IGF-1) carrying an arginine substitution at position 3 and a 13-amino-acid N-terminal ex…
Ipamorelin
RCT sull'uomoCrescita · 711.86 g/mol · t½ 2h
Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; c…
Kisspeptin-10
RCT sull'uomoRicerca (altro) · 1302.44 g/mol · t½ 0.07h
Kisspeptin-10 is the shortest bioactive fragment (10 amino acids) of the endogenous neuropeptide kisspeptin, encoded by the KISS1 gene. It a…
KPV
Modello animaleGuarigione · 342.4 g/mol
KPV is the C-terminal tripeptide (lysine-proline-valine) of the hormone α-MSH, corresponding to its positions 11–13. In cell and rodent mode…
Lanreotid
RCT sull'uomoRicerca (altro) · 1096.34 g/mol
Lanreotide is a synthetic cyclic octapeptide analog of somatostatin. It binds preferentially to the somatostatin receptors SSTR2 and SSTR5 a…
Leuprorelin
RCT sull'uomoRicerca (altro) · 1209.4 g/mol · t½ 3h
Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescript…
Linaclotid
RCT sull'uomoRicerca (altro) · 1526.74 g/mol
Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation…
Liraglutide
RCT sull'uomoMetabolico · 3751 g/mol · t½ 13h
GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 dia…
Lixisenatide
RCT sull'uomoMetabolico · 4858.5 g/mol · t½ 3h
Synthetic exendin-4 analog with a C-terminal lysine extension. Prandial GLP-1 RA focused on postprandial glucose. FDA-approved 2016 as Adlyx…
LL-37
Studio sull'uomoRicerca (altro) · 4493.33 g/mol
LL-37 is the only known human cathelicidin, a 37-amino-acid antimicrobial peptide generated by cleavage of the precursor protein hCAP18. In …
Maridebart Cafraglutide
RCT sull'uomoMetabolico
Maridebart cafraglutide (MariTide, Amgen) is a bispecific molecule: a GLP-1 receptor agonist combined with a GIP receptor antagonist, design…
Matrixyl
RCT sull'uomoCosmetico · 802.06 g/mol
Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally de…
Mazdutide
RCT sull'uomoMetabolico · 4790 g/mol · t½ 132h
Synthetic oxyntomodulin analogue that simultaneously activates the GLP-1 and glucagon receptors (dual agonist). Developed by Innovent Biolog…
Melanotan II
Studio sull'uomoRicerca (altro) · 1024.18 g/mol · t½ 1h
Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection…
MGF (Mechano Growth Factor)
Modello animaleCrescita · 2867.2 g/mol · t½ 0.1h
Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mecha…
Mod GRF (1-29)
Studio sull'uomoCrescita · 3367.9 g/mol · t½ 0.5h
Tetrasubstituted synthetic analogue of GHRH(1-29), traded on the grey market as "CJC-1295 without DAC". Closely related to sermorelin (GHRH …
MOTS-c
Studio sull'uomoRicerca (altro) · 2174.61 g/mol
MOTS-c is a 16-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within the 12S rR…
Nafarelin
RCT sull'uomoRicerca (altro)
Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and cent…
Octreotide
RCT sull'uomoRicerca (altro) · 1019.24 g/mol · t½ 1.7h
Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for ac…
Oxytocin
RCT sull'uomoRicerca (altro) · 1007.19 g/mol · t½ 0.05h
Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for d…
Pasireotid
RCT sull'uomoRicerca (altro) · 1047.21 g/mol
Pasireotide is a multireceptor somatostatin analog binding to four of the five somatostatin receptors (especially SSTR5). It is approved for…
Pemvidutide
Studio sull'uomoMetabolico
Pemvidutide is a 29-amino-acid GLP-1/glucagon dual receptor agonist (Altimmune) under investigation for obesity and the fatty-liver disease …
Petrelintide
RCT sull'uomoMetabolico
Petrelintide is a long-acting amylin analogue (Zealand Pharma, with Roche) for once-weekly subcutaneous use — developed for weight managemen…
Plecanatid
RCT sull'uomoRicerca (altro) · 1682 g/mol
Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idi…
Pramlintid
RCT sull'uomoMetabolico · 3949.4 g/mol
Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes …
Retatrutide
RCT sull'uomoMetabolico · 4731.6 g/mol · t½ 144h
Synthetic triagonist peptide that simultaneously activates the GLP-1, GIP and glucagon receptors. Developed by Eli Lilly; in phase-3 trials …
Sekretin
Studio sull'uomoRicerca (altro) · 3055.5 g/mol
Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent …
Selank
Studio sull'uomoRicerca (altro) · 751.85 g/mol · t½ 0.3h
Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trial…
Semaglutid
RCT sull'uomoMetabolico · 4113.6 g/mol · t½ 165h
Long-acting GLP-1 receptor agonist. Approved as a medicinal product for type-2 diabetes (Ozempic, Rybelsus), chronic weight management (Wego…
Semax
Studio sull'uomoRicerca (altro) · 813.92 g/mol · t½ 0.3h
Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic str…
Sermorelin
RCT sull'uomoCrescita · 3358 g/mol · t½ 0.2h
Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Formerly FDA…
Setmelanotide
RCT sull'uomoMetabolico · 1117.32 g/mol · t½ 11h
Setmelanotide (brand name Imcivree) is a synthetic cyclic octapeptide and an agonist at the melanocortin-4 receptor (MC4R). It was developed…
Sincalide
Studio sull'uomoRicerca (altro) · 1143.29 g/mol
Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimulate gallbla…
SNAP-8
Studio sull'uomoCosmetico · 1075.16 g/mol
Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapep…
Survodutide
RCT sull'uomoMetabolico · 4727 g/mol · t½ 168h
Synthetic peptide that simultaneously activates the GLP-1 and glucagon receptors. Developed by Boehringer Ingelheim and Zealand Pharma; in p…
TB-500
Modello animaleGuarigione · 888 g/mol
Synthetic fragment of the endogenous protein Thymosin Beta-4, specifically the actin-binding sequence. Preclinical models investigate effect…
Teduglutid
RCT sull'uomoRicerca (altro) · 3752.13 g/mol
Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is …
Teriparatid
RCT sull'uomoRicerca (altro) · 4117.8 g/mol · t½ 1h
Teriparatide is the recombinant N-terminal fragment 1-34 of human parathyroid hormone (PTH). It is regulatory-approved and studied in the sc…
Terlipressin
RCT sull'uomoRicerca (altro) · 1227.37 g/mol
Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrictive and is…
Tesamorelin
RCT sull'uomoCrescita · 5135.83 g/mol · t½ 0.4h
Stabilised GHRH analog (growth-hormone-releasing hormone). FDA-approved in 2010 as Egrifta for reduction of abdominal lipohypertrophy in HIV…
Thymalin
Studio sull'uomoGuarigione · 1000 g/mol · t½ 0.5h
Complex of low-molecular polypeptides extracted from calf thymus. Approved in Russia since the 1970s as an immunomodulator. The exact compos…
Thymosin Alpha-1
RCT sull'uomoGuarigione · 3108.32 g/mol · t½ 2h
Synthetic 28-amino-acid peptide identical to a naturally occurring thymus peptide. Approved as Zadaxin in more than 30 countries (not US/EU)…
Thymosin Beta-4
Studio sull'uomoGuarigione · 4921 g/mol
Thymosin Beta-4 (Tβ4) is an endogenous 43-amino-acid peptide regarded as the principal intracellular actin-sequestering factor, involved in …
Tirzepatide
RCT sull'uomoMetabolico · 4813 g/mol · t½ 116h
Synthetic peptide that simultaneously activates the GLP-1 and GIP receptor (dual agonist). Approved in the US and EU for type 2 diabetes (Mo…
Triptorelin
RCT sull'uomoRicerca (altro) · 1311.45 g/mol · t½ 3h
Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s…
Vasopressin
RCT sull'uomoRicerca (altro) · 1084.23 g/mol
Vasopressin (arginine vasopressin, antidiuretic hormone/ADH) is a cyclic nonapeptide hormone that regulates water balance and vascular tone.…
VK2735
RCT sull'uomoMetabolico
VK2735 is a dual GLP-1/GIP receptor agonist from Viking Therapeutics, in development in both subcutaneous and oral forms for obesity.…
Metodo
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