Cerebrolysin
Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free amino acids, produced by standardised enzymatic proteolysis. It is approved in several countries (including Austria, Russia and parts of Asia) for stroke, dementia and traumatic brain injury, but is not FDA-approved in the United States and not centrally approved by the EMA. Its efficacy is contested: Cochrane systematic reviews found no convincing benefit and flagged possible harm signals.
Mechanism of action
Cerebrolysin is a mixture of low-molecular-weight peptides (predominantly below 10 kDa) and free amino acids obtained by enzymatic cleavage of lipid-free porcine brain proteins. The manufacturer and preclinical literature describe a neurotrophic and neuroprotective mode of action said to mimic endogenous neurotrophic factors; cell and animal models have reported effects on neuronal survival, synaptogenesis and anti-apoptotic signalling (including PI3K/Akt). Because it is a complex, incompletely characterised mixture, the precise mechanism in humans remains unclear.
L'evidenza in sintesi
Cosa mostrano gli studi
Dove gli studi divergono
Does Cerebrolysin have a proven clinical benefit in stroke and neurological disease?
Farmacocinetica
Vie di somministrazione nella letteratura
Uso più sicuro e rischi
Eventi avversi noti dagli studi
Interazioni e combinazioni
Stato legale per paese
Calcolatore di ricostituzione
I peptidi arrivano come polvere secca. Una volta disciolti in un liquido (ricostituzione), questo calcolatore risponde a una sola domanda: quanta sostanza c'è in un millilitro di soluzione dopo?
- 1Inserisci la quantità di sostanza del flacone (riportata sull'etichetta).
- 2Inserisci quanto solvente aggiungi.
- 3Risultato = concentrazione in mg per mL.
Cofattori
Questi cofattori si riferiscono alla classe del peptide, non a un uso specifico. Nessuna raccomandazione, nessun dosaggio.
Registro degli studi
Cerebrolysin for acute ischaemic stroke
Cerebrolysin for vascular dementia
Safety and efficacy of Cerebrolysin in acute brain injury and neurorecovery: CAPTAIN I-a randomized, placebo-controlled, double-blind, Asian-Pacific trial
Safety and Efficacy of Cerebrolysin in Early Post-stroke Recovery: a Meta-analysis of Nine Randomized Clinical Trials
Fonti e metodologia
Ricevi nuovi studi su Cerebrolysin
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