Confronto

Epitalon vs. Histrelin

Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.

Identità

Categoria

Ricerca (altro)

N. CAS

307297-39-8

220810-26-4

Peso molecolare

390.35 g/mol

1323.52 g/mol

Emivita

0.3 h

nessun dato

Sequenza

Ala-Glu-Asp-Gly

nessun dato

Meccanismo d'azione

Epitalon

Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.

Histrelin

Continuous GnRH-agonist stimulation downregulates and desensitises the pituitary GnRH receptors — after the initial rise, LH, FSH and the sex hormones fall persistently.

Base di evidenze

Evidenza più alta

Studio sull'uomo

RCT sull'uomo

Studi

di cui sull'uomo

Effetti registrati

Contraddizioni aperte

Eventi avversi documentati

Stato legale

Country	Epitalon	Histrelin
Germania	Non approvato	Su prescrizione
RU	Solo ricerca	—
Stati Uniti	Non approvato	Su prescrizione

Voci complete

Frequently asked questions

What is the difference between Epitalon and Histrelin?: Epitalon is classified as "Ricerca (altro)", while Histrelin is classified as "Ricerca (altro)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Epitalon or Histrelin?: The highest available evidence level is "Studio sull'uomo" for Epitalon and "RCT sull'uomo" for Histrelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Epitalon and Histrelin in Germany and the United States?: Germania: Epitalon — Non approvato, Histrelin — Su prescrizione. Stati Uniti: Epitalon — Non approvato, Histrelin — Su prescrizione. These are factual summaries with source and review date on the individual pages.

Country

Epitalon

Histrelin

Germania

Non approvato

Su prescrizione

Solo ricerca

—

Stati Uniti

Non approvato

Su prescrizione

Frequently asked questions

What is the difference between Epitalon and Histrelin?

Epitalon is classified as "Ricerca (altro)", while Histrelin is classified as "Ricerca (altro)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Epitalon or Histrelin?

The highest available evidence level is "Studio sull'uomo" for Epitalon and "RCT sull'uomo" for Histrelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Epitalon and Histrelin in Germany and the United States?

Germania: Epitalon — Non approvato, Histrelin — Su prescrizione. Stati Uniti: Epitalon — Non approvato, Histrelin — Su prescrizione. These are factual summaries with source and review date on the individual pages.