Confronto
Linaclotid vs. Melanotan II
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
851199-59-2
121062-08-6
Peso molecolare
1526.74 g/mol
1024.18 g/mol
Emivita
nessun dato
1 h
Sequenza
nessun dato
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Meccanismo d'azione
Linaclotid
Linaclotide activates the guanylate cyclase-C receptor on the luminal surface of the intestinal epithelium. This raises cyclic GMP (cGMP), increases secretion of chloride and bicarbonate into the lumen, raises stool fluid content and accelerates transit; pain signaling is also modulated.
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Base di evidenze
Evidenza più alta
RCT sull'uomo
Studio sull'uomo
Studi
0
9
di cui sull'uomo
0
5
Effetti registrati
2
4
Contraddizioni aperte
0
1
Eventi avversi documentati
1
6
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Linaclotid and Melanotan II?
- Linaclotid is classified as "Ricerca (altro)", while Melanotan II is classified as "Ricerca (altro)". Linaclotid: Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Linaclotid or Melanotan II?
- The highest available evidence level is "RCT sull'uomo" for Linaclotid and "Studio sull'uomo" for Melanotan II. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Linaclotid and Melanotan II in Germany and the United States?
- Germania: Linaclotid — Su prescrizione, Melanotan II — Non approvato. Stati Uniti: Linaclotid — Su prescrizione, Melanotan II — Non approvato. These are factual summaries with source and review date on the individual pages.