Confronto
Linaclotid vs. Selank
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
851199-59-2
129954-34-3
Peso molecolare
1526.74 g/mol
751.85 g/mol
Emivita
nessun dato
0.3 h
Sequenza
nessun dato
Thr-Lys-Pro-Arg-Pro-Gly-ProMeccanismo d'azione
Linaclotid
Linaclotide activates the guanylate cyclase-C receptor on the luminal surface of the intestinal epithelium. This raises cyclic GMP (cGMP), increases secretion of chloride and bicarbonate into the lumen, raises stool fluid content and accelerates transit; pain signaling is also modulated.
Selank
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Base di evidenze
Evidenza più alta
RCT sull'uomo
Studio sull'uomo
Studi
0
4
di cui sull'uomo
0
2
Effetti registrati
2
3
Contraddizioni aperte
0
1
Eventi avversi documentati
1
1
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Linaclotid and Selank?
- Linaclotid is classified as "Ricerca (altro)", while Selank is classified as "Ricerca (altro)". Linaclotid: Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with constipation (IBS-C) and chronic idiopathic constipation (CIC). Selank: Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Linaclotid or Selank?
- The highest available evidence level is "RCT sull'uomo" for Linaclotid and "Studio sull'uomo" for Selank. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Linaclotid and Selank in Germany and the United States?
- Germania: Linaclotid — Su prescrizione, Selank — Non approvato. Stati Uniti: Linaclotid — Su prescrizione, Selank — Non approvato. These are factual summaries with source and review date on the individual pages.