Confronto
Melanotan II vs. Oxytocin
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
121062-08-6
50-56-6
Peso molecolare
1024.18 g/mol
1007.19 g/mol
Emivita
1 h
0.05 h
Sequenza
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2Meccanismo d'azione
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Oxytocin
Oxytocin is synthesised in the hypothalamus and released via the posterior pituitary. Peripherally it binds the oxytocin receptor, a G-protein-coupled receptor, and through the phospholipase-C cascade and calcium release triggers contraction of uterine smooth muscle and milk ejection — the pharmacological basis of the obstetric approval. Centrally, oxytocin acts as a neuromodulator and has been linked to social bonding, trust and modulation of stress and anxiety circuits. Its central effects in humans are mechanistically incompletely understood, particularly because it is unclear to what extent peripherally or intranasally administered oxytocin crosses the blood-brain barrier.
Base di evidenze
Evidenza più alta
Studio sull'uomo
RCT sull'uomo
Studi
9
4
di cui sull'uomo
5
4
Effetti registrati
4
3
Contraddizioni aperte
1
1
Eventi avversi documentati
6
0
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Melanotan II and Oxytocin?
- Melanotan II is classified as "Ricerca (altro)", while Oxytocin is classified as "Ricerca (altro)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Oxytocin: Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Oxytocin?
- The highest available evidence level is "Studio sull'uomo" for Melanotan II and "RCT sull'uomo" for Oxytocin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Oxytocin in Germany and the United States?
- Germania: Melanotan II — Non approvato, Oxytocin — Su prescrizione. Stati Uniti: Melanotan II — Non approvato, Oxytocin — Su prescrizione. These are factual summaries with source and review date on the individual pages.