Confronto
MGF (Mechano Growth Factor) vs. Mod GRF (1-29)
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Crescita
Crescita
N. CAS
12-Aminosäuren-C-terminales E-Domänen-Peptid (Sequenz nicht standardisiert)
863288-34-0
Peso molecolare
2867.2 g/mol
3367.9 g/mol
Emivita
0.1 h
0.5 h
Sequenza
YQPPSTNKNTKSQRRKGSTFEERKTyr-D-Ala-Asp-Ala-Ile-Phe-Thr-Gln-Ser-Tyr-Arg-Lys-Val-Leu-Ala-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Leu-Ser-Arg-NH2Meccanismo d'azione
MGF (Mechano Growth Factor)
The IGF-1 gene produces multiple isoforms by alternative splicing. IGF-1Ec is upregulated after mechanical muscle loading; the C-terminal E-domain is cleaved from the mature IGF-1 protein and appears to have independent effects on satellite cells. The exact receptor binding of the E-domain is not established; a classical IGF-1R effect is unlikely since mature IGF-1 is responsible. In cell-culture studies, stimulation of myoblast proliferation and differentiation has been observed.
Mod GRF (1-29)
Synthetic analogue of the first 29 amino acids of growth-hormone-releasing hormone (GHRH 1-29). Four amino-acid substitutions (D-Ala at position 2, Gln at 8, Ala at 15, Leu at 27) are intended to slow degradation by dipeptidyl peptidase-IV and increase enzymatic stability relative to native GHRH. Like the native hormone and sermorelin, it binds the GHRH receptor on somatotroph cells of the anterior pituitary; mechanistically this is expected to stimulate endogenous growth-hormone release. Unlike the DAC-conjugated CJC-1295 variant, it lacks albumin binding, so its duration of action remains short.
Base di evidenze
Evidenza più alta
Modello animale
Studio sull'uomo
Studi
4
4
di cui sull'uomo
0
4
Effetti registrati
3
3
Contraddizioni aperte
1
1
Eventi avversi documentati
1
0
Stato legale
Voci complete
Frequently asked questions
- What is the difference between MGF (Mechano Growth Factor) and Mod GRF (1-29)?
- MGF (Mechano Growth Factor) is classified as "Crescita", while Mod GRF (1-29) is classified as "Crescita". MGF (Mechano Growth Factor): Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market. Mod GRF (1-29): Tetrasubstituted synthetic analogue of GHRH(1-29), traded on the grey market as "CJC-1295 without DAC". Closely related to sermorelin (GHRH 1-29); a short-acting growth-hormone-releasing-hormone analogue often combined with a GHRP/ghrelin mimetic. Not approved as a medicinal product. Direct human trials of this exact analogue are essentially absent; the factual basis relies on related GHRH(1-29) analogues. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, MGF (Mechano Growth Factor) or Mod GRF (1-29)?
- The highest available evidence level is "Modello animale" for MGF (Mechano Growth Factor) and "Studio sull'uomo" for Mod GRF (1-29). A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of MGF (Mechano Growth Factor) and Mod GRF (1-29) in Germany and the United States?
- Germania: MGF (Mechano Growth Factor) — Non approvato, Mod GRF (1-29) — Non approvato. Stati Uniti: MGF (Mechano Growth Factor) — Non approvato, Mod GRF (1-29) — Solo ricerca. These are factual summaries with source and review date on the individual pages.