Confronto
Setmelanotide vs. VK2735
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Metabolico
Metabolico
N. CAS
920014-72-8
nessun dato
Peso molecolare
1117.32 g/mol
nessun dato
Emivita
11 h
nessun dato
Sequenza
Ac-Arg-Cys(1)-D-Ala-His-D-Phe-Arg-Trp-Cys(1)-NH2 (zyklisches Oktapeptid, Disulfidbrücke Cys2–Cys8)nessun dato
Meccanismo d'azione
Setmelanotide
Setmelanotide is an agonist at the melanocortin-4 receptor (MC4R), a central receptor of the hypothalamic melanocortin pathway involved in the control of energy balance, satiety and body weight. In certain genetic defects (e.g. in POMC, PCSK1 or LEPR), the natural activation of MC4R is reduced. Setmelanotide activates MC4R directly, thereby bypassing the upstream defect. This description is mechanistic and neutral and does not constitute a recommendation for use.
VK2735
VK2735 activates both the GLP-1 and the GIP receptor — a dual mechanism similar to that of tirzepatide, suppressing appetite and food intake.
Base di evidenze
Evidenza più alta
RCT sull'uomo
RCT sull'uomo
Studi
4
1
di cui sull'uomo
3
1
Effetti registrati
3
2
Contraddizioni aperte
1
0
Eventi avversi documentati
3
1
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Setmelanotide and VK2735?
- Setmelanotide is classified as "Metabolico", while VK2735 is classified as "Metabolico". Setmelanotide: Setmelanotide (brand name Imcivree) is a synthetic cyclic octapeptide and an agonist at the melanocortin-4 receptor (MC4R). It was developed and approved as a prescription medicine for chronic weight management in rare genetic forms of obesity within the MC4R signalling pathway (including POMC, PCSK1 and LEPR deficiency as well as Bardet-Biedl syndrome). The following information is provided for informational and educational purposes only. VK2735: VK2735 is a dual GLP-1/GIP receptor agonist from Viking Therapeutics, in development in both subcutaneous and oral forms for obesity. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Setmelanotide or VK2735?
- The highest available evidence level is "RCT sull'uomo" for Setmelanotide and "RCT sull'uomo" for VK2735. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Setmelanotide and VK2735 in Germany and the United States?
- Germania: Setmelanotide — Su prescrizione, VK2735 — Non approvato. Stati Uniti: Setmelanotide — Su prescrizione, VK2735 — Non approvato. These are factual summaries with source and review date on the individual pages.