Сравнение
Cetrorelix vs. Leuprorelin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
120287-85-6
53714-56-0
Молекулярная масса
1431.06 g/mol
1209.4 g/mol
Период полувыведения
нет данных
3 h
Последовательность
нет данных
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtМеханизм действия
Cetrorelix
Cetrorelix competitively and immediately blocks the pituitary GnRH receptor, rapidly suppressing LH and FSH release — without the initial hormone surge ('flare') of GnRH agonists.
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
0
4
из них на людях
0
4
Зафиксированные эффекты
2
4
Открытые противоречия
0
1
Задокументированные нежелательные явления
1
3
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Cetrorelix and Leuprorelin?
- Cetrorelix is classified as "Исследования (прочее)", while Leuprorelin is classified as "Исследования (прочее)". Cetrorelix: Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during controlled ovarian stimulation. Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cetrorelix or Leuprorelin?
- The highest available evidence level is "РКИ на людях" for Cetrorelix and "РКИ на людях" for Leuprorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cetrorelix and Leuprorelin in Germany and the United States?
- Германия: Cetrorelix — Рецептурный, Leuprorelin — Рецептурный. США: Cetrorelix — Рецептурный, Leuprorelin — Рецептурный. These are factual summaries with source and review date on the individual pages.