Confronto
Cetrorelix vs. Leuprorelin
Due peptidi a confronto — identità, base di evidenze, stato legale ed eventi avversi noti.
Identità
Categoria
Ricerca (altro)
Ricerca (altro)
N. CAS
120287-85-6
53714-56-0
Peso molecolare
1431.06 g/mol
1209.4 g/mol
Emivita
nessun dato
3 h
Sequenza
nessun dato
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtMeccanismo d'azione
Cetrorelix
Cetrorelix competitively and immediately blocks the pituitary GnRH receptor, rapidly suppressing LH and FSH release — without the initial hormone surge ('flare') of GnRH agonists.
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Base di evidenze
Evidenza più alta
RCT sull'uomo
RCT sull'uomo
Studi
0
4
di cui sull'uomo
0
4
Effetti registrati
2
4
Contraddizioni aperte
0
1
Eventi avversi documentati
1
3
Stato legale
Voci complete
Frequently asked questions
- What is the difference between Cetrorelix and Leuprorelin?
- Cetrorelix is classified as "Ricerca (altro)", while Leuprorelin is classified as "Ricerca (altro)". Cetrorelix: Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH surge during controlled ovarian stimulation. Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Cetrorelix or Leuprorelin?
- The highest available evidence level is "RCT sull'uomo" for Cetrorelix and "RCT sull'uomo" for Leuprorelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Cetrorelix and Leuprorelin in Germany and the United States?
- Germania: Cetrorelix — Su prescrizione, Leuprorelin — Su prescrizione. Stati Uniti: Cetrorelix — Su prescrizione, Leuprorelin — Su prescrizione. These are factual summaries with source and review date on the individual pages.