Сравнение
Epitalon vs. Icatibant
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
307297-39-8
138614-30-9
Молекулярная масса
390.35 g/mol
1304.52 g/mol
Период полувыведения
0.3 h
нет данных
Последовательность
Ala-Glu-Asp-Glyнет данных
Механизм действия
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Icatibant
Icatibant competitively blocks the bradykinin B2 receptor. Because bradykinin mediates the vascular permeability, swelling and pain typical of hereditary angioedema, the blockade interrupts the acute attack.
Доказательная база
Наивысшая доказательность
Исследование на людях
РКИ на людях
Исследования
4
1
из них на людях
1
1
Зафиксированные эффекты
4
1
Открытые противоречия
1
0
Задокументированные нежелательные явления
1
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Epitalon and Icatibant?
- Epitalon is classified as "Исследования (прочее)", while Icatibant is classified as "Исследования (прочее)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Icatibant: Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks of hereditary angioedema (HAE). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Icatibant?
- The highest available evidence level is "Исследование на людях" for Epitalon and "РКИ на людях" for Icatibant. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Icatibant in Germany and the United States?
- Германия: Epitalon — Не одобрено, Icatibant — Рецептурный. США: Epitalon — Не одобрено, Icatibant — Рецептурный. These are factual summaries with source and review date on the individual pages.