Сравнение
Epitalon vs. Plecanatid
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
307297-39-8
467426-54-6
Молекулярная масса
390.35 g/mol
1682 g/mol
Период полувыведения
0.3 h
нет данных
Последовательность
Ala-Glu-Asp-Glyнет данных
Механизм действия
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Доказательная база
Наивысшая доказательность
Исследование на людях
РКИ на людях
Исследования
4
0
из них на людях
1
0
Зафиксированные эффекты
4
2
Открытые противоречия
1
1
Задокументированные нежелательные явления
1
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Epitalon and Plecanatid?
- Epitalon is classified as "Исследования (прочее)", while Plecanatid is classified as "Исследования (прочее)". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Plecanatid?
- The highest available evidence level is "Исследование на людях" for Epitalon and "РКИ на людях" for Plecanatid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Plecanatid in Germany and the United States?
- Германия: Epitalon — Не одобрено, Plecanatid — Не одобрено. США: Epitalon — Не одобрено, Plecanatid — Рецептурный. These are factual summaries with source and review date on the individual pages.