Comparison
Epitalon vs. Plecanatid
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
307297-39-8
467426-54-6
Molecular weight
390.35 g/mol
1682 g/mol
Half-life
0.3 h
no data
Sequence
Ala-Glu-Asp-Glyno data
Mechanism of action
Epitalon
Postulated mechanisms include modulation of gene expression in pinealocytes, telomerase activation (observed in cell culture studies) and influence on melatonin synthesis. A defined primary receptor is not established; the mechanistic basis rests on in-vitro and animal data from the Khavinson group.
Plecanatid
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
4
0
of which in humans
1
0
Effects recorded
4
2
Open conflicts
1
1
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Epitalon and Plecanatid?
- Epitalon is classified as "Research other", while Plecanatid is classified as "Research other". Epitalon: Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated in the Russian research and anti-ageing context; Western controlled trials are largely absent. No medicines approval in EU or US. Plecanatid: Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Epitalon or Plecanatid?
- The highest available evidence level is "Human trial" for Epitalon and "Human RCT" for Plecanatid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Epitalon and Plecanatid in Germany and the United States?
- Germany: Epitalon — Unapproved, Plecanatid — Unapproved. United States: Epitalon — Unapproved, Plecanatid — Prescription. These are factual summaries with source and review date on the individual pages.