Lexicon
Peptides A–Z
All catalogued peptides alphabetically. Filter by evidence tier or click a letter.
A5
Abaloparatid
Human RCTResearch other · Abaloparatide
Abaloparatide is a synthetic 34-amino-acid analogue of parathyroid hormone-related protein (PTHrP 1-34). It is regulatory-approved…
Afamelanotide
Human RCTResearch other · Scenesse
Afamelanotide (brand name Scenesse) is a synthetic 13-amino-acid analogue of α-melanocyte-stimulating hormone (α-MSH) and a melano…
Amycretin
Human RCTMetabolic · NN0487
Amycretin is a unimolecular GLP-1 and amylin receptor agonist from Novo Nordisk — in development both as a once-weekly subcutaneou…
AOD-9604
Human RCTGrowth · HGH Fragment 176-191
Synthetic 16-amino-acid peptide corresponding to the C-terminal fragment of human growth hormone (hGH 176-191). Originally develop…
Argireline
Human trialCosmetic · Acetyl Hexapeptide-3
Synthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-…
B3
BPC-157
Animal modelHealing · Body Protection Compound 157
Synthetic pentadecapeptide (15 amino acids) derived from a sequence of a gastric-juice protein. Studied predominantly in animal mo…
Bremelanotide
Human RCTResearch other · PT-141
Synthetic cyclic heptapeptide acting as a non-selective melanocortin-receptor agonist. FDA-approved in 2019 as Vyleesi for hypoact…
Buserelin
Human RCTResearch other · Suprefact
Buserelin is a synthetic GnRH agonist (including as a nasal spray). It is used in endometriosis, hormone-dependent prostate cancer…
C7
Cagrilintide
Human RCTMetabolic · AM833
Synthetic long-acting amylin analog being developed in combination with semaglutide (CagriSema). Phase 3 trials for obesity and ty…
CagriSema
Human RCTMetabolic · Cagrilintid/Semaglutid
CagriSema is a fixed-dose combination of the amylin analogue cagrilintide and the GLP-1 agonist semaglutide (Novo Nordisk), in lat…
Calcitonin (Lachs)
Human RCTResearch other · Salmon Calcitonin
Salmon calcitonin is a synthetically produced 32-amino-acid peptide hormone that corresponds to the body's own calcitonin but exhi…
Carbetocin
Human RCTResearch other · Duratocin
Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injec…
Cerebrolysin
Human RCTResearch other · FPF-1070
Cerebrolysin (FPF-1070) is not a single peptide but a porcine-brain-derived preparation of low-molecular-weight peptides and free …
Cetrorelix
Human RCTResearch other · Cetrotide
Cetrorelix is a synthetic decapeptide and GnRH antagonist. It is used in assisted reproduction (IVF) to prevent a premature LH sur…
CJC-1295
Human trialGrowth · CJC-1295 mit DAC
Long-acting synthetic GHRH analogue modified for albumin binding (DAC). Stimulates endogenous growth-hormone release. Pharmacodyna…
D4
Degarelix
Human RCTResearch other · Firmagon
Degarelix (trade name Firmagon) is a synthetic decapeptide and a gonadotropin-releasing hormone (GnRH) receptor antagonist. Unlike…
Desmopressin
Human RCTResearch other · DDAVP
Desmopressin (DDAVP) is a synthetic analogue of the endogenous hormone vasopressin (antidiuretic hormone, ADH). Deamination of the…
DSIP
Human trialResearch other · Delta Sleep Inducing Peptide
Synthetic nonapeptide isolated in 1977 by Guido Monnier and Marcel Schoenenberger from the blood of rabbits in delta sleep. Despit…
Dulaglutide
Human RCTMetabolic · LY2189265
GLP-1 receptor agonist designed as a fusion protein of two modified GLP-1(7-37) sequences covalently linked to a human IgG4-Fc fra…
E7
Ecnoglutide
Human RCTMetabolic · XW003
Ecnoglutide (XW003) is a long-acting, cAMP-signalling-biased GLP-1 analogue from Sciwind Biosciences. Derived from GLP-1(7-37) wit…
Efinopegdutide
Human RCTMetabolic · MK-6024
Efinopegdutide (MK-6024, formerly JNJ-64565111 / HM12525A) is a once-weekly dual agonist at the GLP-1 and glucagon receptors, deve…
Elamipretide
Human RCTResearch other · SS-31
Elamipretide (SS-31, MTP-131, formerly Bendavia) is a synthetic, mitochondria-targeting tetrapeptide (sequence D-Arg-Dmt-Lys-Phe-N…
Eloralintide
Human RCTMetabolic · LY3841136
Eloralintide is a selective, long-acting amylin receptor agonist from Eli Lilly for once-weekly subcutaneous use — under investiga…
Enfuvirtid
Human RCTResearch other · Enfuvirtide
Enfuvirtide is a synthetic 36-amino-acid peptide and the first HIV-1 fusion inhibitor. It binds the HR1 region of the viral envelo…
Epitalon
Human trialResearch other · Epithalon
Synthetic tetrapeptide (Ala-Glu-Asp-Gly) derived from the pineal extract epithalamin (V. Khavinson, St. Petersburg). Investigated …
Exenatide
Human RCTMetabolic · AC2993
Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 recepto…
F2
Follistatin (FST)
Human trialGrowth · FST
Follistatin is an endogenous glycosylated binding protein (~35 kDa, considerably larger than typical peptides) that binds and neut…
FOXO4-DRI
Animal modelResearch other · FOXO4-D-Retro-Inverso
Synthetic peptide with D-Retro-Inverso structure (all amino acids as D-form, sequence reversed), developed in 2017 as an experimen…
G8
Ganirelix
Human RCTResearch other · Orgalutran
Ganirelix is a synthetic decapeptide and GnRH antagonist. In assisted reproduction (IVF) it prevents the premature LH surge during…
GHK-Cu
Human trialCosmetic · Copper Tripeptide-1
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on…
GHRP-2
Human trialGrowth · Pralmorelin
Synthetic hexapeptide of the GH secretagogue family. Approved in Japan as GHRP Kaken as a diagnostic test for GH deficiency. Not a…
GHRP-6
Human trialGrowth · Growth Hormone Releasing Peptide 6
Synthetic hexapeptide that founded the class of growth-hormone-releasing peptides (GHRPs). Cyril Bowers identified GHRP-6 in the l…
Glepaglutide
Human RCTResearch other · ZP1848
Glepaglutide is a long-acting GLP-2 analogue (Zealand Pharma) intended to reduce the need for parenteral support in short bowel sy…
Glucagon
Human RCTMetabolic · Glukagon
Glucagon is a 29-amino-acid pancreatic hormone produced by the alpha cells of the islets of Langerhans. It is the physiological co…
Gonadorelin
Human trialResearch other · GnRH
Gonadorelin is the synthetic decapeptide with an amino-acid sequence identical to endogenous gonadotropin-releasing hormone (GnRH/…
Goserelin
Human RCTResearch other · Zoladex
Goserelin is a synthetic decapeptide and an agonist of gonadotropin-releasing hormone (GnRH). The medical literature describes it …
H3
Hexarelin
Human trialGrowth · HEX
Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and …
Histrelin
Human RCTResearch other · Supprelin LA
Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (S…
Humanin
Human trialResearch other · HN
Humanin is a 24-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within…
I3
Icatibant
Human RCTResearch other · Firazyr
Icatibant is a synthetic decapeptide and selective antagonist of the bradykinin B2 receptor. It is approved to treat acute attacks…
IGF-1 LR3
Animal modelGrowth · Long R3 IGF-1
Synthetic analogue of insulin-like growth factor 1 (IGF-1) carrying an arginine substitution at position 3 and a 13-amino-acid N-t…
Ipamorelin
Human RCTGrowth · NNC 26-0161
Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP su…
K2
Kisspeptin-10
Human RCTResearch other · Metastin 45-54
Kisspeptin-10 is the shortest bioactive fragment (10 amino acids) of the endogenous neuropeptide kisspeptin, encoded by the KISS1 …
KPV
Animal modelHealing · Lys-Pro-Val
KPV is the C-terminal tripeptide (lysine-proline-valine) of the hormone α-MSH, corresponding to its positions 11–13. In cell and r…
L6
Lanreotid
Human RCTResearch other · Lanreotide
Lanreotide is a synthetic cyclic octapeptide analog of somatostatin. It binds preferentially to the somatostatin receptors SSTR2 a…
Leuprorelin
Human RCTResearch other · Leuprolide
Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved…
Linaclotid
Human RCTResearch other · Linaclotide
Linaclotide is a 14-amino-acid peptide and guanylate cyclase-C (GC-C) agonist. It is approved for irritable bowel syndrome with co…
Liraglutide
Human RCTMetabolic · NN2211
GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for …
Lixisenatide
Human RCTMetabolic · AVE0010
Synthetic exendin-4 analog with a C-terminal lysine extension. Prandial GLP-1 RA focused on postprandial glucose. FDA-approved 201…
LL-37
Human trialResearch other · Cathelicidin LL-37
LL-37 is the only known human cathelicidin, a 37-amino-acid antimicrobial peptide generated by cleavage of the precursor protein h…
M7
Maridebart Cafraglutide
Human RCTMetabolic · MariTide
Maridebart cafraglutide (MariTide, Amgen) is a bispecific molecule: a GLP-1 receptor agonist combined with a GIP receptor antagoni…
Matrixyl
Human RCTCosmetic · Palmitoyl Pentapeptide-4
Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Struc…
Mazdutide
Human RCTMetabolic · IBI362
Synthetic oxyntomodulin analogue that simultaneously activates the GLP-1 and glucagon receptors (dual agonist). Developed by Innov…
Melanotan II
Human trialResearch other · MT-II
Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-…
MGF (Mechano Growth Factor)
Animal modelGrowth · IGF-1 Ec
Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies a…
Mod GRF (1-29)
Human trialGrowth · Modified GRF 1-29
Tetrasubstituted synthetic analogue of GHRH(1-29), traded on the grey market as "CJC-1295 without DAC". Closely related to sermore…
MOTS-c
Human trialResearch other · Mitochondrial ORF of the 12S rRNA type-c
MOTS-c is a 16-amino-acid mitochondrial-encoded peptide (mitochondrial-derived peptide, MDP) whose open reading frame lies within …
N1
O2
Octreotide
Human RCTResearch other · SMS 201-995
Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 19…
Oxytocin
Human RCTResearch other · OXT
Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been appr…
P5
Pasireotid
Human RCTResearch other · Pasireotide
Pasireotide is a multireceptor somatostatin analog binding to four of the five somatostatin receptors (especially SSTR5). It is ap…
Pemvidutide
Human trialMetabolic · ALT-801
Pemvidutide is a 29-amino-acid GLP-1/glucagon dual receptor agonist (Altimmune) under investigation for obesity and the fatty-live…
Petrelintide
Human RCTMetabolic · ZP8396
Petrelintide is a long-acting amylin analogue (Zealand Pharma, with Roche) for once-weekly subcutaneous use — developed for weight…
Plecanatid
Human RCTResearch other · Plecanatide
Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for c…
Pramlintid
Human RCTMetabolic · Pramlintide
Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2…
R1
S9
Sekretin
Human trialResearch other · Secretin
Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnos…
Selank
Human trialResearch other · TP-7
Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western pha…
Semaglutid
Human RCTMetabolic · Semaglutide
Long-acting GLP-1 receptor agonist. Approved as a medicinal product for type-2 diabetes (Ozempic, Rybelsus), chronic weight manage…
Semax
Human trialResearch other · MEHFPGP
Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for isc…
Sermorelin
Human RCTGrowth · GHRH(1-29)
Synthetic analogue of the first 29 amino acids of human GHRH. Stimulates pulsatile growth-hormone secretion from the pituitary. Fo…
Setmelanotide
Human RCTMetabolic · Imcivree
Setmelanotide (brand name Imcivree) is a synthetic cyclic octapeptide and an agonist at the melanocortin-4 receptor (MC4R). It was…
Sincalide
Human trialResearch other · Kinevac
Sincalide is the synthetic C-terminal octapeptide of the hormone cholecystokinin (CCK-8). As Kinevac it is FDA-approved to stimula…
SNAP-8
Human trialCosmetic · Acetyl Octapeptide-3
Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acet…
Survodutide
Human RCTMetabolic · BI 456906
Synthetic peptide that simultaneously activates the GLP-1 and glucagon receptors. Developed by Boehringer Ingelheim and Zealand Ph…
T10
TB-500
Animal modelHealing · Thymosin Beta-4 Fragment
Synthetic fragment of the endogenous protein Thymosin Beta-4, specifically the actin-binding sequence. Preclinical models investig…
Teduglutid
Human RCTResearch other · Teduglutide
Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal muco…
Teriparatid
Human RCTResearch other · Teriparatide
Teriparatide is the recombinant N-terminal fragment 1-34 of human parathyroid hormone (PTH). It is regulatory-approved and studied…
Terlipressin
Human RCTResearch other · Terlivaz
Terlipressin is a 12-amino-acid vasopressin analog and prodrug of lysine-vasopressin. As a V1 receptor agonist it is vasoconstrict…
Tesamorelin
Human RCTGrowth · TH9507
Stabilised GHRH analog (growth-hormone-releasing hormone). FDA-approved in 2010 as Egrifta for reduction of abdominal lipohypertro…
Thymalin
Human trialHealing · Vilon (verwandtes Di-Peptid)
Complex of low-molecular polypeptides extracted from calf thymus. Approved in Russia since the 1970s as an immunomodulator. The ex…
Thymosin Alpha-1
Human RCTHealing · TA1
Synthetic 28-amino-acid peptide identical to a naturally occurring thymus peptide. Approved as Zadaxin in more than 30 countries (…
Thymosin Beta-4
Human trialHealing · TB4
Thymosin Beta-4 (Tβ4) is an endogenous 43-amino-acid peptide regarded as the principal intracellular actin-sequestering factor, in…
Tirzepatide
Human RCTMetabolic · LY3298176
Synthetic peptide that simultaneously activates the GLP-1 and GIP receptor (dual agonist). Approved in the US and EU for type 2 di…
Triptorelin
Human RCTResearch other · Decapeptyl
Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since…
V2
Vasopressin
Human RCTResearch other · Arginin-Vasopressin
Vasopressin (arginine vasopressin, antidiuretic hormone/ADH) is a cyclic nonapeptide hormone that regulates water balance and vasc…
VK2735
Human RCTMetabolic · VK2735 (Viking)
VK2735 is a dual GLP-1/GIP receptor agonist from Viking Therapeutics, in development in both subcutaneous and oral forms for obesi…