Human RCT
Mensch
Prevention of postpartum haemorrhage wit 2009
Prevents postpartum hemorrhage comparably to oxytocin — as a practical single dose (large non-inferiority trial).
What does NOT follow: Obstetric use under clinical supervision.
Peptide entry · Research other
Carbetocin
Duratocin · Pabal · Lonactene
Highest evidence
Human RCT
Studies recorded
1· 1 in humans
Legal status · US
UnapprovedScientific context only. Not medical advice, not a recommendation to use.
At a glance
Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Approved in Canada and the UK among others, NOT in the US.
Researched for
Prevention of postpartum hemorrhageUterine contraction after birth
Official status
US: Unapproved
Not FDA-approved; oxytocin is used in the US.
At a glance
Overview
What is it?
Carbetocin is a long-acting synthetic oxytocin analog (half-life ~40 minutes). It prevents postpartum hemorrhage as a single injection. Approved in Canada and the UK among others, NOT in the US.
How is it meant to work? →
Carbetocin is an oxytocin receptor agonist with prolonged duration. It triggers a sustained contraction of the uterus after birth, preventing atonic hemorrhage — unlike oxytocin, without a multi-hour infusion.
What do studies show? →
Human RCTPrevents postpartum hemorrhage comparably to oxytocin — as a practical single dose (large non-inferiority trial).
What do users report?
No documented community reports.
01
Mechanism of action
Carbetocin is an oxytocin receptor agonist with prolonged duration. It triggers a sustained contraction of the uterus after birth, preventing atonic hemorrhage — unlike oxytocin, without a multi-hour infusion.
02
Evidence at a glance
Reading note. The distribution shows on which evidence tier each observation sits. Strong colours mark stronger evidence — weaker tiers are deliberately visible, not hidden.
03
What the studies show
Human trial
Mensch
Longer duration of action than oxytocin (no continuous infusion needed).
What does NOT follow: A practical advantage; mechanism identical to oxytocin.
05
Pharmacokinetics
Theoretical concentration curve at a half-life of 0.67 h. Pure pharmacokinetic model — not a dosing recommendation.
Open in PK tool →Start time: t₀ = 0h
Repeat interval: off (single dose)
06d
Safer use & risks
Risk notes for harm reduction — descriptive, not a usage or dosing guide.
This substance is approved (in at least one country) — use belongs in medical hands, within the approved indication and a physician-set dose.
Online numbers are not a benchmark
Amounts from TikTok, YouTube and forums are mostly imitation rather than data — and are often wrongly derived from animal studies (µg/kg). Not a reliable benchmark for humans.
Sterility & infection risk
Injection solutions prepared or stored non-sterile carry an infection and abscess risk. Contamination is common with grey-market product.
Unknown product quality
Research-/grey-market product is not quality-tested: identity, purity and actual content are often unknown, and counterfeits occur.
Mind interactions
Combinations with medications or pre-existing conditions can carry risks (see the Interactions section). Clarify with a doctor beforehand.
Warning signs — seek medical help
With persistent pain, redness/swelling at the injection site, fever, shortness of breath, racing heart, chest pain or allergic reactions, seek medical help immediately.
A doctor, not a forum
Concrete questions about use and amount belong in a conversation with a doctor — not in a comment thread.
07
Known adverse events from studies
Factual reporting of what studies observed. Not a safety statement for individual use.
Human trial
Flushing, nausea, abdominal pain, drop in blood pressure (context-dependent)
Typical of oxytocin receptor agonists in the obstetric setting.
häufig
07b
Interactions & combinations
Documented interactions and contraindications from studies, prescribing information and guidelines. Where no data exists, this is stated.
Reporting of risks, NOT a combination guide. The absence of an entry does not mean „safe to combine“ but „not sufficiently studied“.
No documented interactions recorded
We have not yet found robustly documented interactions for this peptide. This does NOT mean none exist — the data is limited.
11
Legal status by country
12
Reconstitution calculator
Pure mg/mL maths — works like a calculator. Not a usage recommendation.
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
- 1Enter the vial's substance amount (printed on the label).
- 2Enter how much solvent you add.
- 3Result = concentration in mg per mL.
Printed on the label
/
Liquid you add
=
2.50
mg / mL
5 mg in 2 mL gives 2.50 mg/mL — each millilitre contains 2.50 mg of substance.
14
Study register
Human trialReview
· 2009
Prevention of postpartum haemorrhage with the oxytocin analogue carbetocin
Findings:Carbetocin effectively and practically prevents postpartum hemorrhage as a single dose.
15
Sources & method
Last reviewed
2026-06-12
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