Research topics
What peptides are studied for — grouped by indication, mechanism of action, endpoint or surrogate marker. Each topic links to all peptides with available studies.
Indication
Repair processes in skin, tendon, ligament or mucosal injury. Endpoints are healing speed, mechanical strength and histological markers. Peptides in this area a…
Recovery from tendon or ligament injury, quantified mechanically (tensile load) and histologically (collagen organisation). Practically relevant in sports and t…
Protection and healing of gastric and intestinal mucosa, e.g. against NSAID-induced damage or ulcerative models. Evidence almost entirely from animal models.…
Chronic metabolic disease with impaired insulin sensitivity and secretion. Key parameter is HbA1c. GLP-1 agonists have robust evidence in this area from large p…
Reduction or stabilisation of body weight in overweight or obesity. Clinical endpoints: percentage weight loss, waist circumference, comorbidities. Weight regai…
Umbrella term for interventions against visible and biological aging processes. Endpoints range from skin parameters (wrinkles, hydration) to body composition a…
Promotion of scalp hair growth or density. Popular topic in peptide communities; controlled trials are small and mostly industry-bound.…
Heterogeneous tumour group with hormone secretion (carcinoid syndrome, VIPomas, insulinomas). Somatostatin analogs are a central therapeutic pillar.…
Sleep latency, slow-wave proportion and subjective recovery. Described preclinically for some peptides (DSIP, GH secretagogues), but controlled human data on cl…
Anxiolytic and stress-hormone effects. A few peptides from the Russian research tradition (selank) have been studied clinically; Western RCTs to modern standard…
Attention and memory performance. A group of Russian Pro-Gly-Pro peptides (semax, selank) has been investigated; replication in Western RCTs is limited.…
Sexual desire and arousal. With bremelanotide (Vyleesi) an FDA-approved indication exists here (HSDD in pre-menopausal women); the mechanistic origin was a chan…
Training-induced muscle hypertrophy and recovery. GH secretagogues and IGF-1 related peptides are heavily discussed in bodybuilding forums; randomised human stu…
Excessive growth-hormone secretion, usually from a pituitary adenoma. Somatostatin analogs (octreotide, lanreotide) have been the standard therapy here for deca…
Hormonal suppression therapy in advanced prostate cancer. GnRH analogs (triptorelin, leuprolide) act via down-regulation of pituitary LH/FSH secretion.…
Central precocious puberty in children. GnRH analogs (triptorelin) delay the pituitary LH/FSH axis — an approved paediatric indication.…
Endpoint
Mechanism
Formation of new blood vessels from existing ones. Mechanistically central to wound healing and tissue repair — but also relevant to tumour biology, which is wh…
Stimulation of endogenous growth-hormone secretion from the pituitary. Surrogate markers: plasma GH and IGF-1 levels. Clinical outcome studies on functional end…
Incretin receptor with G-protein-coupled signalling cascade. Activation glucose-dependently stimulates insulin secretion, inhibits glucagon, delays gastric empt…
Modification of immune responses via T-cell maturation, Toll-like receptors or cytokine profiles. Thymus-derived peptides or synthetic analogs are studied in he…
Family of G-protein-coupled receptors (MC1R–MC5R) with roles in pigmentation, energy homeostasis, steroidogenesis and sexual function. MC4R in the CNS is a targ…
Protection of nerve tissue under ischaemia, injury or neurodegenerative stress. Several peptides are studied preclinically (semax, selank); clinical translation…