Collagen synthesis
Collagen production by fibroblasts — relevant for wound healing, skin regeneration and anti-aging endpoints. Frequently quantified in cell-culture models.
Peptides on this topic
4 peptides researched for this topicSynthetic hexapeptide marketed as a topical anti-wrinkle ingredient (e.g. by Lipotec/Lubrizol). Mechanism modelled on the SNAP-25-blocking action of botulinum toxin, but with substantially lower potency and without intramuscular effect. EU-compliant as a cosmetic ingredient (CosIng), not approved as a medicine.
- Human trialVisual reduction of wrinkle depth in dynamic areas (forehead, periorbital) reported in industry-sponsored cosmetic studies
Endogenous tripeptide (glycyl-L-histidyl-L-lysine) that chelates copper(II) ions. Studied in skin models and small human trials on collagen synthesis, skin regeneration and wound healing; permitted as a cosmetic ingredient in the EU.
- In vitroPromotion of collagen synthesis in fibroblast cultures
- Human trialChanges in cutaneous parameters under topical application
Synthetic pentapeptide (KTTKS) with a palmitoyl modification, marketed as a topical anti-aging ingredient (Lipotec/Sederma). Structurally derived from a collagen-I fragment; intended to stimulate fibroblast activity. Cosmetic ingredient, not a medicine.
- In vitroStimulation of collagen synthesis in human dermal fibroblast cultures reproducibly documented
- Human RCTVisual reduction of wrinkle depth and subjective improvement of skin quality reported in a randomised double-blind topical study over 12 weeks
Synthetic octapeptide marketed as a topical anti-wrinkle ingredient (Centerchem/Lipotec). Structurally related to Argireline (Acetyl Hexapeptide-3) but with two additional C-terminal amino acids. Manufacturer marketing positions SNAP-8 as an 'improved' Argireline variant.
- Human trialVisual reduction of expression wrinkles documented in manufacturer-sponsored studies on various skin areas