Topic · Indication

Prostate cancer

Hormonal suppression therapy in advanced prostate cancer. GnRH analogs (triptorelin, leuprolide) act via down-regulation of pituitary LH/FSH secretion.

Peptides on this topic

1 peptide researched for this topic

Triptorelin

Research other · 4 studies

Human RCT

Synthetic decapeptide GnRH agonist with increased affinity over native gonadotropin-releasing hormone. FDA- and EMA-approved since the 1980s for prostate cancer, endometriosis and precocious puberty.

Relevant observations

Human RCTSuppression of testosterone into the castration range (<50 ng/dL) within 4 weeks in men with prostate cancer documented
Human RCTReduction of endometriosis pain and lesion size demonstrated versus placebo in randomised trials