Prostate cancer
Hormonal suppression therapy in advanced prostate cancer. GnRH analogs (triptorelin, leuprolide) act via down-regulation of pituitary LH/FSH secretion.
Peptides on this topic
6 péptidos con investigación sobre este temaLa buserelina es un agonista de la GnRH usado en el cáncer de próstata, la endometriosis y la reproducción asistida.
- ECA en humanosSuppresses sex hormones after an initial flare — the basis of efficacy in endometriosis and prostate cancer.
- Estudio en humanosAlso available as a nasal spray — like nafarelin, one of the few nasally administered GnRH agonists.
El degarelix es un antagonista de la GnRH aprobado para el cáncer de próstata; reduce con rapidez la testosterona (Firmagon).
- ECA en humanosIn a randomized phase III study, degarelix lowered testosterone without the initial surge (flare) seen with GnRH agonists and achieved castrate-range suppression over the study year, comparable to leuprorelin.
- ECA en humanosIn the phase III study, degarelix produced a faster initial decline in testosterone and prostate-specific antigen (PSA) than the agonist comparator arm.
El goserelina es un agonista de la GnRH (Zoladex) aprobado para el cáncer de próstata y de mama y para la endometriosis.
- Estudio en humanosHuman studies observed suppression of circulating sex hormones down to castration levels.
- ECA en humanosIn a randomized trial, premenopausal patients receiving concurrent chemotherapy showed a lower rate of ovarian failure when goserelin was added.
La histrelina es un agonista de la GnRH en implante anual, aprobado para la pubertad precoz central y el cáncer de próstata avanzado.
- ECA en humanosSuppresses sex hormones via a yearly implant — in precocious puberty and prostate cancer.
- Estudio en humanosImplant form (once a year) instead of regular injections.
El leuprorelina (leuprolida) es un agonista de la GnRH aprobado para el cáncer de próstata, la endometriosis y la pubertad precoz.
- ECA en humanosWith continuous exposure, LH and FSH are suppressed, with subsequent lowering of sex steroids.
- ECA en humanosIn randomized endometriosis studies, leuprorelin was associated with greater reduction of pain parameters versus placebo.
El triptorelina es un agonista de la GnRH aprobado para el cáncer de próstata, la endometriosis y la pubertad precoz.
- ECA en humanosSuppression of testosterone into the castration range (<50 ng/dL) within 4 weeks in men with prostate cancer documented
- ECA en humanosReduction of endometriosis pain and lesion size demonstrated versus placebo in randomised trials