Anxiety & Stress
Anxiolytic and stress-hormone effects. A few peptides from the Russian research tradition (selank) have been studied clinically; Western RCTs to modern standards are rare.
Peptides on this topic
2 peptides researched for this topicOxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials.
- Human RCTInduction and augmentation of uterine contractions and reduction of postpartum bleeding in obstetric use
- Human RCTNo consistent benefit on core social symptoms of autism spectrum disorder in controlled trials
Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature.
- Human trialReduction of anxiety symptoms versus placebo reported in Russian clinical pilot studies
- Animal modelAnxiolytic effects in open-field and elevated-plus-maze tests documented in rats