Selank
Synthetic heptapeptide derived from natural tuftsin. Approved as an anxiolytic (Selank) in Russia and some CIS states. Western phase-3 trials are absent; efficacy assessment relies on Russian research literature.
Mechanism of action
Selank is a glyproline-tuftsin analog. Proposed mechanisms include modulation of the GABAergic system, effects on serotonin bioavailability, and influence on enkephalinases. Animal studies show anxiolytic and neuroprotective markers; a clear receptor target is not established.
Evidence at a glance
What the studies show
Where studies disagree
Do the anxiolytic/nootropic effects replicate outside the predominantly Russian studies?
Pharmacokinetics
Theoretical concentration curve at a half-life of 0.3 h. Pure pharmacokinetic model — not a dosing recommendation.
Open in PK tool →Routes of administration in the literature
Safer use & risks
Known adverse events from studies
Interactions & combinations
Anecdotal observations
Legal status by country
Reconstitution calculator
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
- 1Enter the vial's substance amount (printed on the label).
- 2Enter how much solvent you add.
- 3Result = concentration in mg per mL.
Cofactors
These cofactors relate to the peptide class, not to a specific use. No recommendation, no dosing.
Study register
Efficacy and safety of Selank in patients with generalized anxiety disorder
Synthesis and biological activity of selank — an analog of the endogenous immunomodulatory peptide tuftsin
The Pro-Gly-Pro neuropeptide selank and its influence on emotional behaviour in animal models
Immunomodulatory effects of Selank in patients with anxiety-asthenic disorders
Sources & method
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