Semax
Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent.
Mechanism of action
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence at a glance
What the studies show
Where studies disagree
Do the nootropic/neuroprotective effects replicate outside the predominantly Russian studies?
Pharmacokinetics
Theoretical concentration curve at a half-life of 0.3 h. Pure pharmacokinetic model — not a dosing recommendation.
Open in PK tool →Routes of administration in the literature
Safer use & risks
Known adverse events from studies
Interactions & combinations
Anecdotal observations
Legal status by country
Reconstitution calculator
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
- 1Enter the vial's substance amount (printed on the label).
- 2Enter how much solvent you add.
- 3Result = concentration in mg per mL.
Cofactors
These cofactors relate to the peptide class, not to a specific use. No recommendation, no dosing.
Study register
Semax — synthetic ACTH(4-10) heptapeptide analog with neurotropic activity
Memory facilitation by Semax in healthy humans
Comparative analysis of expression of certain genes in murine brain after Semax administration
Sources & method
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