Muscle building
Training-induced muscle hypertrophy and recovery. GH secretagogues and IGF-1 related peptides are heavily discussed in bodybuilding forums; randomised human studies with hypertrophy endpoints are the rare exception, not the rule.
Peptides on this topic
5 peptides researched for this topicSynthetic hexapeptide of the GH secretagogue family. Approved in Japan as GHRP Kaken as a diagnostic test for GH deficiency. Not available as a medicine outside Japan.
- Human trialRobust acute GH rise after single intravenous or subcutaneous administration documented in healthy volunteers and in GH-deficient patients
Synthetic hexapeptide that founded the class of growth-hormone-releasing peptides (GHRPs). Cyril Bowers identified GHRP-6 in the late 1970s as the first orally and parenterally active GH secretagogue with no structural similarity to GHRH. Never approved as a medicine; downstream analogs (GHRP-2, hexarelin, ipamorelin) were pursued clinically.
- Human trialRobust acute GH rise after single intravenous or subcutaneous administration documented in healthy volunteers and in GH-deficient patients
Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine.
- Human trialAcute rise of serum GH and IGF-1 after single dose observed in healthy volunteers and GH-deficient patients
Synthetic pentapeptide and selective growth-hormone secretagogue. Developed at Novo Nordisk in the 1990s as a pentapeptide GHRP successor; clinical development was discontinued after phase 2 (post-operative ileus).
- Human trialSelective GH stimulation without significant rise in ACTH/cortisol/prolactin documented in phase-1 studies in healthy volunteers
Synthetic peptide corresponding to the C-terminal E-domain of the IGF-1 splice variant IGF-1Ec. Described in preclinical studies as a 'mechano-induced' skeletal muscle repair factor. No marketing approval; clinical use largely confined to the black market.
- In vitroActivation of muscle satellite cells and enhanced myoblast proliferation documented in cell-culture studies
- Animal modelImproved muscle regeneration after injury observed in mouse models with local intramuscular injection