GHRP-2
Synthetic hexapeptide of the GH secretagogue family. Approved in Japan as GHRP Kaken as a diagnostic test for GH deficiency. Not available as a medicine outside Japan.
Mechanism of action
GHRP-2 binds with high affinity to the GH secretagogue receptor (GHSR-1a) in the pituitary and hypothalamus. Activation leads to rapid release of pulsatile growth hormone. Unlike GHRH, GHRP-2 acts via a separate pathway and can be combined synergistically with GHRH to elicit maximal GH responses in provocation tests.
Evidence at a glance
What the studies show
Pharmacokinetics
Theoretical concentration curve at a half-life of 0.5 h. Pure pharmacokinetic model — not a dosing recommendation.
Open in PK tool →Routes of administration in the literature
Safer use & risks
Known adverse events from studies
Interactions & combinations
Risks & hygiene aspects in the literature
WADA status
Anecdotal observations
Legal status by country
Reconstitution calculator
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
- 1Enter the vial's substance amount (printed on the label).
- 2Enter how much solvent you add.
- 3Result = concentration in mg per mL.
Cofactors
These cofactors relate to the peptide class, not to a specific use. No recommendation, no dosing.
Study register
Stimulation of growth hormone release by GHRP-2 in healthy subjects
Effects of eight months treatment with graded doses of a growth hormone (GH)-releasing peptide in GH-deficient children
Diagnostic studies with intravenous and intranasal growth hormone-releasing peptide-2 in children of short stature
Growth hormone releasing peptide-2 (GHRP-2), like ghrelin, increases food intake in healthy men
Sources & method
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