Scientific context only. Not medical advice, not a recommendation to use.
At a glance
Synthetic hexapeptide of the growth-hormone secretagogue (GHRP) family. In the 1990s investigated as an acromegaly diagnostic and for GH deficiency. Not an approved medicine.
Researched for
GH stimulationCardioprotection in animal modelsPituitary function diagnostics
Official status
US: Unapproved
No FDA approval. On the WADA prohibited list as a GH secretagogue in competition and training sport.
Hexarelin is a synthetic analog of the GHRP-6 family binding both the GH secretagogue receptor (GHSR-1a) and CD36. GHSR activation in the pituitary releases pulsatile growth hormone. Via CD36 in endothelium and myocardium, cardioprotective effects have been described in animal studies.
02
Evidence at a glance
Reading note. The distribution shows on which evidence tier each observation sits. Strong colours mark stronger evidence — weaker tiers are deliberately visible, not hidden.
3 observations · 2 tiers
Human trial
2
Animal model
1
03
What the studies show
Human trial
Mensch
Ghigo E. et al. 1994
Acute rise of serum GH and IGF-1 after single dose observed in healthy volunteers and GH-deficient patients
What does NOT follow: Acute effect; tachyphylaxis (loss of response) reported after chronic administration.
Animal model
Ratte
Cardiac protective effect in ischaemia-reperfusion models in rats documented (reduction of infarct size)
What does NOT follow: Mechanistically attributed to CD36; no replication in controlled human trials.
Human trial
Mensch
Stimulation of ACTH and cortisol secretion in a subpopulation of study participants
What does NOT follow: Non-selective endocrine effect; not a therapeutic objective.
05
Pharmacokinetics
Theoretical concentration curve at a half-life of 0.9 h. Pure pharmacokinetic model — not a dosing recommendation.
Which routes of administration the available studies describe — neutral reporting, not a usage guide.
Subcutaneous
Used subcutaneously for GH provocation in early phase-1 and phase-2 studies.
Intranasal
Intranasal formulations were tested in some early studies.
07
Known adverse events from studies
Factual reporting of what studies observed. Not a safety statement for individual use.
Human trial
Stimulation of ACTH/cortisol/prolactin
Hexarelin is not selective; multiple endocrine axes respond.
in Studien dokumentiert
07b
Interactions & combinations
Documented interactions and contraindications from studies, prescribing information and guidelines. Where no data exists, this is stated.
Reporting of risks, NOT a combination guide. The absence of an entry does not mean „safe to combine“ but „not sufficiently studied“.
No documented interactions recorded
We have not yet found robustly documented interactions for this peptide. This does NOT mean none exist — the data is limited.
08
Risks & hygiene aspects in the literature
What regulatory and scientific literature reports on risks, sterility and identity in non-pharmaceutical sources — descriptive, not a hygiene guide.
WADA status
Hexarelin is on the WADA prohibited list under S2 (peptide hormones and growth factors). Use in sport has sporting-law consequences independent of civil-law status.
10
Anecdotal observations
Weakest evidence tier — not supported by studies
Reading note. This section gathers popular claims from communities and forums. They are explicitly marked as weakest-tier evidence. Unblinded self-reports are particularly prone to placebo, recall and confirmation biases.
Why no amounts or protocols are listed here. We deliberately show only WHAT communities report — not in what amount or how it is used. Anecdotal "doses" or "biohacker protocols" are neither verified nor standardised nor safe; publishing them would be a usage guide, which we do not provide on principle. Specific amounts belong in a conversation with a doctor, not in a forum.
Community forums claim hexarelin produces a stronger GH response than other GHRPs.
frequently repeated in English-language forums
Not supported by studies: This claim is not supported by controlled comparison trials; acute effects resemble those of other GHRPs.
11
Legal status by country
Country
Status
Note
Checked
United States
Unapproved
No FDA approval. On the WADA prohibited list as a GH secretagogue in competition and training sport.
2026-05-22
Germany
Unapproved
No EMA approval. Distribution as a 'research chemical' is legally problematic.
2026-05-22
Australia
Banned
TGA status: SUSMP Schedule 4. WADA-prohibited.
2026-05-22
12
Reconstitution calculator
Pure mg/mL maths — works like a calculator. Not a usage recommendation.
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
1Enter the vial's substance amount (printed on the label).
2Enter how much solvent you add.
3Result = concentration in mg per mL.
Printed on the label
/
Liquid you add
=
2.50
mg / mL
5 mg in 2 mL gives 2.50 mg/mL — each millilitre contains 2.50 mg of substance.