Human RCT
Mensch
Relieves CIC and IBS-C (FDA-approved).
What does NOT follow: Approved indications in adults.
Peptide entry · Research other
Plecanatid
Plecanatide · Trulance · SP-304
Highest evidence
Human RCT
Studies recorded
0
Legal status · US
PrescriptionScientific context only. Not medical advice, not a recommendation to use.
At a glance
Plecanatide is a 16-amino-acid analog of the body's own uroguanylin and a guanylate cyclase-C (GC-C) agonist. It is approved for chronic idiopathic constipation (CIC) and IBS with constipation (IBS-C).
Researched for
Chronic constipation (CIC)IBS with constipation (IBS-C)
Official status
US: Prescription
FDA-approved (CIC 2017, IBS-C 2018, Trulance).
At a glance
01
Mechanism of action
Plecanatide is structurally analogous to the body's own uroguanylin and, like it, activates the GC-C receptor at the gut surface, raising cGMP and fluid secretion. Its pH-dependent activity shifts the effect toward the proximal small intestine.
02
Evidence at a glance
Reading note. The distribution shows on which evidence tier each observation sits. Strong colours mark stronger evidence — weaker tiers are deliberately visible, not hidden.
03
What the studies show
Theoretical
—
As a uroguanylin analog with pH-dependent activity, a potentially more physiological profile is discussed.
What does NOT follow: Whether this clinically yields less diarrhea than linaclotide is not established by large head-to-head trials.
04
Where studies disagree
Open question
Does plecanatide cause less diarrhea than linaclotide?
POSITION A
The pH-dependent, uroguanylin-like action could theoretically be milder/more physiological.
POSITION B
Large head-to-head trials are lacking; in practice diarrhea occurs with both GC-C agonists.
CURRENT STATE · Both are considered effective in CIC/IBS-C; a clear tolerability advantage is not established.
05
Pharmacokinetics
No robust pharmacokinetic human data available. A model curve is not invented.
06d
Safer use & risks
Risk notes for harm reduction — descriptive, not a usage or dosing guide.
This substance is approved (in at least one country) — use belongs in medical hands, within the approved indication and a physician-set dose.
Online numbers are not a benchmark
Amounts from TikTok, YouTube and forums are mostly imitation rather than data — and are often wrongly derived from animal studies (µg/kg). Not a reliable benchmark for humans.
Sterility & infection risk
Injection solutions prepared or stored non-sterile carry an infection and abscess risk. Contamination is common with grey-market product.
Unknown product quality
Research-/grey-market product is not quality-tested: identity, purity and actual content are often unknown, and counterfeits occur.
Mind interactions
Combinations with medications or pre-existing conditions can carry risks (see the Interactions section). Clarify with a doctor beforehand.
Warning signs — seek medical help
With persistent pain, redness/swelling at the injection site, fever, shortness of breath, racing heart, chest pain or allergic reactions, seek medical help immediately.
A doctor, not a forum
Concrete questions about use and amount belong in a conversation with a doctor — not in a comment thread.
07
Known adverse events from studies
Factual reporting of what studies observed. Not a safety statement for individual use.
Human RCT
Diarrhea
Most common effect of GC-C agonists; a direct mechanistic consequence of increased secretion.
häufig
07b
Interactions & combinations
Documented interactions and contraindications from studies, prescribing information and guidelines. Where no data exists, this is stated.
Reporting of risks, NOT a combination guide. The absence of an entry does not mean „safe to combine“ but „not sufficiently studied“.
No documented interactions recorded
We have not yet found robustly documented interactions for this peptide. This does NOT mean none exist — the data is limited.
11
Legal status by country
12
Reconstitution calculator
Pure mg/mL maths — works like a calculator. Not a usage recommendation.
Peptides ship as a dry powder. Once dissolved in a liquid (reconstitution), this calculator answers a single question: how much substance is in one millilitre of solution afterwards?
- 1Enter the vial's substance amount (printed on the label).
- 2Enter how much solvent you add.
- 3Result = concentration in mg per mL.
Printed on the label
/
Liquid you add
=
2.50
mg / mL
5 mg in 2 mL gives 2.50 mg/mL — each millilitre contains 2.50 mg of substance.
15
Sources & method
Last reviewed
2026-06-11
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