Сравнение
Exenatide vs. Liraglutide
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
141758-74-9
204656-20-2
Молекулярная масса
4186.6 g/mol
3751 g/mol
Период полувыведения
2.4 h
13 h
Последовательность
HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPSHAEGTFTSDVSSYLEGQAAKEFIAWLVRGRGМеханизм действия
Exenatide
Exenatide is a 39-amino-acid peptide with about 53% sequence homology to human GLP-1. A glycine substitution at position 2 prevents dipeptidyl-peptidase-IV cleavage and extends the half-life from native GLP-1 (minutes) to about 2.4 hours. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon and delays gastric emptying.
Liraglutide
Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and protects against DPP-4 degradation. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon secretion, delays gastric emptying and modulates central satiety.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
5
из них на людях
4
4
Зафиксированные эффекты
3
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
2
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Exenatide and Liraglutide?
- Exenatide is classified as "Метаболизм", while Liraglutide is classified as "Метаболизм". Exenatide: Synthetic version of exendin-4, originally isolated from the saliva of the Gila monster (Heloderma suspectum). First GLP-1 receptor agonist, FDA-approved 2005 as Byetta. Weekly depot form Bydureon approved 2012. Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Exenatide or Liraglutide?
- The highest available evidence level is "РКИ на людях" for Exenatide and "РКИ на людях" for Liraglutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Exenatide and Liraglutide in Germany and the United States?
- Германия: Exenatide — Рецептурный, Liraglutide — Рецептурный. США: Exenatide — Рецептурный, Liraglutide — Рецептурный. These are factual summaries with source and review date on the individual pages.