Сравнение

Histrelin vs. Semax

Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.

Идентичность

Категория

Исследования (прочее)

Номер CAS

220810-26-4

80714-61-0

Молекулярная масса

1323.52 g/mol

813.92 g/mol

Период полувыведения

нет данных

0.3 h

Последовательность

нет данных

Met-Glu-His-Phe-Pro-Gly-Pro

Механизм действия

Histrelin

Continuous GnRH-agonist stimulation downregulates and desensitises the pituitary GnRH receptors — after the initial rise, LH, FSH and the sex hormones fall persistently.

Semax

Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.

Доказательная база

Наивысшая доказательность

РКИ на людях

Исследование на людях

Исследования

из них на людях

Зафиксированные эффекты

Открытые противоречия

Задокументированные нежелательные явления

Правовой статус

Country	Histrelin	Semax
Германия	Рецептурный	Не одобрено
RU	—	Рецептурный
США	Рецептурный	Не одобрено

Полные записи

Frequently asked questions

What is the difference between Histrelin and Semax?: Histrelin is classified as "Исследования (прочее)", while Semax is classified as "Исследования (прочее)". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
Which peptide is better supported by science, Histrelin or Semax?: The highest available evidence level is "РКИ на людях" for Histrelin and "Исследование на людях" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
What is the legal status of Histrelin and Semax in Germany and the United States?: Германия: Histrelin — Рецептурный, Semax — Не одобрено. США: Histrelin — Рецептурный, Semax — Не одобрено. These are factual summaries with source and review date on the individual pages.

Country

Histrelin

Semax

Германия

Рецептурный

Не одобрено

—

Рецептурный

США

Рецептурный

Не одобрено

Frequently asked questions

What is the difference between Histrelin and Semax?

Histrelin is classified as "Исследования (прочее)", while Semax is classified as "Исследования (прочее)". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.

Which peptide is better supported by science, Histrelin or Semax?

The highest available evidence level is "РКИ на людях" for Histrelin and "Исследование на людях" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.

What is the legal status of Histrelin and Semax in Germany and the United States?

Германия: Histrelin — Рецептурный, Semax — Не одобрено. США: Histrelin — Рецептурный, Semax — Не одобрено. These are factual summaries with source and review date on the individual pages.