Comparison
Histrelin vs. Semax
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
220810-26-4
80714-61-0
Molecular weight
1323.52 g/mol
813.92 g/mol
Half-life
no data
0.3 h
Sequence
no data
Met-Glu-His-Phe-Pro-Gly-ProMechanism of action
Histrelin
Continuous GnRH-agonist stimulation downregulates and desensitises the pituitary GnRH receptors — after the initial rise, LH, FSH and the sex hormones fall persistently.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Evidence base
Highest evidence
Human RCT
Human trial
Studies
0
4
of which in humans
0
2
Effects recorded
2
3
Open conflicts
0
1
Documented adverse events
1
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Histrelin and Semax?
- Histrelin is classified as "Research other", while Semax is classified as "Research other". Histrelin: Histrelin is a nonapeptide GnRH agonist delivered as a once-yearly implant. Approved for central precocious puberty in children (Supprelin LA) and advanced prostate cancer (Vantas). Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Histrelin or Semax?
- The highest available evidence level is "Human RCT" for Histrelin and "Human trial" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Histrelin and Semax in Germany and the United States?
- Germany: Histrelin — Prescription, Semax — Unapproved. United States: Histrelin — Prescription, Semax — Unapproved. These are factual summaries with source and review date on the individual pages.