Сравнение
Leuprorelin vs. Semax
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
53714-56-0
80714-61-0
Молекулярная масса
1209.4 g/mol
813.92 g/mol
Период полувыведения
3 h
0.3 h
Последовательность
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtMet-Glu-His-Phe-Pro-Gly-ProМеханизм действия
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
4
4
из них на людях
4
2
Зафиксированные эффекты
4
3
Открытые противоречия
1
1
Задокументированные нежелательные явления
3
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Leuprorelin and Semax?
- Leuprorelin is classified as "Исследования (прочее)", while Semax is classified as "Исследования (прочее)". Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Leuprorelin or Semax?
- The highest available evidence level is "РКИ на людях" for Leuprorelin and "Исследование на людях" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Leuprorelin and Semax in Germany and the United States?
- Германия: Leuprorelin — Рецептурный, Semax — Не одобрено. США: Leuprorelin — Рецептурный, Semax — Не одобрено. These are factual summaries with source and review date on the individual pages.