Vergelijking
Leuprorelin vs. Semax
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Onderzoek (overig)
Onderzoek (overig)
CAS-nr.
53714-56-0
80714-61-0
Molecuulmassa
1209.4 g/mol
813.92 g/mol
Halfwaardetijd
3 h
0.3 h
Sequentie
Pyr-His-Trp-Ser-Tyr-D-Leu-Leu-Arg-Pro-NHEtMet-Glu-His-Phe-Pro-Gly-ProWerkingsmechanisme
Leuprorelin
Leuprorelin is a GnRH-receptor agonist. After binding to pituitary GnRH receptors, it first causes a transient surge in luteinizing hormone (LH) and follicle-stimulating hormone (FSH) release — the so-called flare. With continuous, non-pulsatile exposure the receptors are downregulated and desensitized, suppressing gonadotropin secretion and consequently lowering sex steroids (testosterone or estradiol) to low levels. This mechanism underlies the literature-described use in hormone-dependent conditions.
Semax
Semax is a tetracosactide fragment analog without hormonal activity at MC2R. Proposed mechanisms include elevation of BDNF and NGF in hippocampus and striatum (in animal models), modulation of dopamine metabolism, and neuroprotective effects via anti-apoptotic pathways. A clear primary receptor is not established.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane studie
Studies
4
4
waarvan bij mensen
4
2
Geregistreerde effecten
4
3
Openstaande tegenstrijdigheden
1
1
Gedocumenteerde bijwerkingen
3
1
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Leuprorelin and Semax?
- Leuprorelin is classified as "Onderzoek (overig)", while Semax is classified as "Onderzoek (overig)". Leuprorelin: Leuprorelin (also leuprolide) is a synthetic nonapeptide analogue of gonadotropin-releasing hormone (GnRH/LHRH). It is an approved prescription medicine in several jurisdictions, including for advanced prostate cancer, endometriosis, uterine fibroids and central precocious puberty. This page neutrally summarizes the evidence base and legal status and is not a usage or dosing recommendation. Semax: Synthetic heptapeptide derived from the N-terminal fragment of adrenocorticotropic hormone (ACTH 4-10). Approved in Russia for ischaemic stroke, cognitive function and ADHD in children. Western phase-3 trials absent. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Leuprorelin or Semax?
- The highest available evidence level is "Humane RCT" for Leuprorelin and "Humane studie" for Semax. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Leuprorelin and Semax in Germany and the United States?
- Duitsland: Leuprorelin — Op recept, Semax — Niet goedgekeurd. Verenigde Staten: Leuprorelin — Op recept, Semax — Niet goedgekeurd. These are factual summaries with source and review date on the individual pages.