Сравнение
Liraglutide vs. Pemvidutide
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
204656-20-2
нет данных
Молекулярная масса
3751 g/mol
нет данных
Период полувыведения
13 h
нет данных
Последовательность
HAEGTFTSDVSSYLEGQAAKEFIAWLVRGRGнет данных
Механизм действия
Liraglutide
Liraglutide is a synthetic GLP-1 analog with 97% sequence identity to human GLP-1. A fatty-acid side chain (C16) on Lys-26 reversibly binds serum albumin and protects against DPP-4 degradation. GLP-1 receptor activation glucose-dependently stimulates insulin secretion, inhibits glucagon secretion, delays gastric emptying and modulates central satiety.
Pemvidutide
The GLP-1 component suppresses appetite while the glucagon component raises energy expenditure and acts directly on hepatic fat metabolism — the combination is intended to mimic the complementary effects of diet and exercise.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
5
1
из них на людях
4
1
Зафиксированные эффекты
3
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
1
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Liraglutide and Pemvidutide?
- Liraglutide is classified as "Метаболизм", while Pemvidutide is classified as "Метаболизм". Liraglutide: GLP-1 receptor agonist with a half-life of about 13 hours. The first daily (not weekly) modern GLP-1 RA — approved as Victoza for type 2 diabetes (2010) and Saxenda for obesity (2014). Pemvidutide: Pemvidutide is a 29-amino-acid GLP-1/glucagon dual receptor agonist (Altimmune) under investigation for obesity and the fatty-liver disease MASH. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Liraglutide or Pemvidutide?
- The highest available evidence level is "РКИ на людях" for Liraglutide and "Исследование на людях" for Pemvidutide. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Liraglutide and Pemvidutide in Germany and the United States?
- Германия: Liraglutide — Рецептурный, Pemvidutide — Не одобрено. США: Liraglutide — Рецептурный, Pemvidutide — Не одобрено. These are factual summaries with source and review date on the individual pages.