Сравнение
Mazdutide vs. Pramlintid
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Метаболизм
Метаболизм
Номер CAS
2259884-03-0
151126-32-8
Молекулярная масса
4790 g/mol
3949.4 g/mol
Период полувыведения
132 h
нет данных
Последовательность
synthetisches Oxyntomodulin-Analogon (39 Aminosäuren) mit Fettsäureseitenketteнет данных
Механизм действия
Mazdutide
Mazdutide is a dual agonist at the GLP-1 and glucagon receptors and is structurally derived from the gut hormone oxyntomodulin. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secretion at elevated blood glucose, and modulation of appetite and gastric emptying. The glucagon component can influence energy expenditure and hepatic lipid and glucose metabolism. A fatty-acid side chain enables albumin binding and the weekly administration interval.
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
4
0
из них на людях
4
0
Зафиксированные эффекты
4
2
Открытые противоречия
0
1
Задокументированные нежелательные явления
0
2
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Mazdutide and Pramlintid?
- Mazdutide is classified as "Метаболизм", while Pramlintid is classified as "Метаболизм". Mazdutide: Synthetic oxyntomodulin analogue that simultaneously activates the GLP-1 and glucagon receptors (dual agonist). Developed by Innovent Biologics and Eli Lilly. In China the NMPA approved mazdutide on 27 June 2025 for chronic weight management; a further filing for type 2 diabetes is under review in China. Outside China the substance remains in clinical development. Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Mazdutide or Pramlintid?
- The highest available evidence level is "РКИ на людях" for Mazdutide and "РКИ на людях" for Pramlintid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Mazdutide and Pramlintid in Germany and the United States?
- Германия: Mazdutide — Только для исследований, Pramlintid — Не одобрено. США: Mazdutide — Только для исследований, Pramlintid — Рецептурный. These are factual summaries with source and review date on the individual pages.