Vergelijking
Mazdutide vs. Pramlintid
Twee peptiden naast elkaar — identiteit, bewijsbasis, juridische status en bekende bijwerkingen.
Identiteit
Categorie
Metabool
Metabool
CAS-nr.
2259884-03-0
151126-32-8
Molecuulmassa
4790 g/mol
3949.4 g/mol
Halfwaardetijd
132 h
geen gegevens
Sequentie
synthetisches Oxyntomodulin-Analogon (39 Aminosäuren) mit Fettsäureseitenkettegeen gegevens
Werkingsmechanisme
Mazdutide
Mazdutide is a dual agonist at the GLP-1 and glucagon receptors and is structurally derived from the gut hormone oxyntomodulin. The GLP-1 component mediates glucose-dependent insulin secretion, inhibition of glucagon secretion at elevated blood glucose, and modulation of appetite and gastric emptying. The glucagon component can influence energy expenditure and hepatic lipid and glucose metabolism. A fatty-acid side chain enables albumin binding and the weekly administration interval.
Pramlintid
Pramlintide mimics the beta-cell hormone amylin, which is co-secreted with insulin. It slows gastric emptying, suppresses postprandial glucagon release and promotes satiety — thereby blunting post-meal blood-glucose spikes.
Bewijsbasis
Hoogste bewijs
Humane RCT
Humane RCT
Studies
4
0
waarvan bij mensen
4
0
Geregistreerde effecten
4
2
Openstaande tegenstrijdigheden
0
1
Gedocumenteerde bijwerkingen
0
2
Juridische status
Volledige vermeldingen
Frequently asked questions
- What is the difference between Mazdutide and Pramlintid?
- Mazdutide is classified as "Metabool", while Pramlintid is classified as "Metabool". Mazdutide: Synthetic oxyntomodulin analogue that simultaneously activates the GLP-1 and glucagon receptors (dual agonist). Developed by Innovent Biologics and Eli Lilly. In China the NMPA approved mazdutide on 27 June 2025 for chronic weight management; a further filing for type 2 diabetes is under review in China. Outside China the substance remains in clinical development. Pramlintid: Pramlintide is a synthetic analog of the hormone amylin. It is used as an adjunct to mealtime insulin therapy in type 1 and type 2 diabetes and, among other things, slows gastric emptying. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Mazdutide or Pramlintid?
- The highest available evidence level is "Humane RCT" for Mazdutide and "Humane RCT" for Pramlintid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Mazdutide and Pramlintid in Germany and the United States?
- Duitsland: Mazdutide — Alleen onderzoek, Pramlintid — Niet goedgekeurd. Verenigde Staten: Mazdutide — Alleen onderzoek, Pramlintid — Op recept. These are factual summaries with source and review date on the individual pages.