Сравнение
Melanotan II vs. Nafarelin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
121062-08-6
нет данных
Молекулярная масса
1024.18 g/mol
нет данных
Период полувыведения
1 h
нет данных
Последовательность
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2нет данных
Механизм действия
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Nafarelin
Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.
Доказательная база
Наивысшая доказательность
Исследование на людях
РКИ на людях
Исследования
9
0
из них на людях
5
0
Зафиксированные эффекты
4
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
6
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Melanotan II and Nafarelin?
- Melanotan II is classified as "Исследования (прочее)", while Nafarelin is classified as "Исследования (прочее)". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Nafarelin?
- The highest available evidence level is "Исследование на людях" for Melanotan II and "РКИ на людях" for Nafarelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Nafarelin in Germany and the United States?
- Германия: Melanotan II — Не одобрено, Nafarelin — Рецептурный. США: Melanotan II — Не одобрено, Nafarelin — Рецептурный. These are factual summaries with source and review date on the individual pages.