Comparison
Melanotan II vs. Nafarelin
Two peptides side-by-side — identity, evidence base, legal status and known adverse events.
Identity
Category
Research other
Research other
CAS no.
121062-08-6
no data
Molecular weight
1024.18 g/mol
no data
Half-life
1 h
no data
Sequence
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH2no data
Mechanism of action
Melanotan II
Melanotan II binds non-selectively to all five melanocortin-receptor subtypes (MC1R-MC5R). Via MC1R in melanocytes, eumelanin synthesis is stimulated (pigmenting effect). Via MC4R and MC3R in the CNS, appetite, sexual function and blood pressure are modulated. The cyclic structure and D-amino acids increase stability compared to natural α-MSH.
Nafarelin
Nafarelin is a potent GnRH agonist: after an initial stimulation ('flare'), continuous receptor occupancy leads to downregulation and thereby suppression of LH, FSH and the downstream sex hormones.
Evidence base
Highest evidence
Human trial
Human RCT
Studies
9
0
of which in humans
5
0
Effects recorded
4
2
Open conflicts
1
0
Documented adverse events
6
1
Legal status
Full entries
Frequently asked questions
- What is the difference between Melanotan II and Nafarelin?
- Melanotan II is classified as "Research other", while Nafarelin is classified as "Research other". Melanotan II: Cyclic hepta-peptide and non-selective melanocortin-receptor agonist. Originally researched at the University of Arizona as a sun-protection concept — never approved as a medicine. Widespread on the black market; regulatory warnings for cardiovascular and oncological risks. Nafarelin: Nafarelin is a GnRH agonist and the only member of this class delivered as a nasal spray. It is approved for treating endometriosis and central precocious puberty. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Melanotan II or Nafarelin?
- The highest available evidence level is "Human trial" for Melanotan II and "Human RCT" for Nafarelin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Melanotan II and Nafarelin in Germany and the United States?
- Germany: Melanotan II — Unapproved, Nafarelin — Prescription. United States: Melanotan II — Unapproved, Nafarelin — Prescription. These are factual summaries with source and review date on the individual pages.