Сравнение
Octreotide vs. Teduglutid
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
83150-76-9
197922-42-2
Молекулярная масса
1019.24 g/mol
3752.13 g/mol
Период полувыведения
1.7 h
нет данных
Последовательность
D-Phe-Cys-Phe-D-Trp-Lys-Thr-Cys-Thr(ol)нет данных
Механизм действия
Octreotide
Octreotide is a cyclic octapeptide that selectively binds somatostatin-receptor subtypes SSTR2 and SSTR5. Via G-protein-coupled signalling, adenylyl cyclase is inhibited, reducing the secretion of multiple hormones (growth hormone, IGF-1, glucagon, insulin, VIP, serotonin). Structural stabilisation via a disulfide bridge and D-amino acids extends the half-life relative to natural somatostatin (minutes to several hours).
Teduglutid
Teduglutide activates the GLP-2 receptor, promoting growth and regeneration of small-intestinal villi, increasing nutrient and fluid absorption and thereby reducing dependence on parenteral nutrition. The glycine substitution at position 2 makes it resistant to rapid breakdown by DPP-4.
Доказательная база
Наивысшая доказательность
РКИ на людях
РКИ на людях
Исследования
5
2
из них на людях
4
2
Зафиксированные эффекты
3
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
2
2
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Octreotide and Teduglutid?
- Octreotide is classified as "Исследования (прочее)", while Teduglutid is classified as "Исследования (прочее)". Octreotide: Synthetic octapeptide somatostatin analog with a longer half-life than endogenous somatostatin. FDA- and EMA-approved since the 1980s for acromegaly and neuroendocrine tumours. Teduglutid: Teduglutide is a DPP-4-resistant analog of GLP-2 (glucagon-like peptide-2). It promotes growth and function of the intestinal mucosa and is approved for treating short bowel syndrome. This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Octreotide or Teduglutid?
- The highest available evidence level is "РКИ на людях" for Octreotide and "РКИ на людях" for Teduglutid. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Octreotide and Teduglutid in Germany and the United States?
- Германия: Octreotide — Рецептурный, Teduglutid — Рецептурный. США: Octreotide — Рецептурный, Teduglutid — Рецептурный. These are factual summaries with source and review date on the individual pages.