Сравнение
Oxytocin vs. Sekretin
Два пептида рядом — идентичность, доказательная база, правовой статус и известные нежелательные явления.
Идентичность
Категория
Исследования (прочее)
Исследования (прочее)
Номер CAS
50-56-6
нет данных
Молекулярная масса
1007.19 g/mol
3055.5 g/mol
Период полувыведения
0.05 h
нет данных
Последовательность
Cys-Tyr-Ile-Gln-Asn-Cys-Pro-Leu-Gly-NH2нет данных
Механизм действия
Oxytocin
Oxytocin is synthesised in the hypothalamus and released via the posterior pituitary. Peripherally it binds the oxytocin receptor, a G-protein-coupled receptor, and through the phospholipase-C cascade and calcium release triggers contraction of uterine smooth muscle and milk ejection — the pharmacological basis of the obstetric approval. Centrally, oxytocin acts as a neuromodulator and has been linked to social bonding, trust and modulation of stress and anxiety circuits. Its central effects in humans are mechanistically incompletely understood, particularly because it is unclear to what extent peripherally or intranasally administered oxytocin crosses the blood-brain barrier.
Sekretin
Secretin binds the Gs-coupled secretin receptor (SCTR) on pancreatic duct cells, opens CFTR chloride channels and triggers secretion of bicarbonate-rich pancreatic fluid and bile flow.
Доказательная база
Наивысшая доказательность
РКИ на людях
Исследование на людях
Исследования
4
0
из них на людях
4
0
Зафиксированные эффекты
3
2
Открытые противоречия
1
0
Задокументированные нежелательные явления
0
1
Правовой статус
Полные записи
Frequently asked questions
- What is the difference between Oxytocin and Sekretin?
- Oxytocin is classified as "Исследования (прочее)", while Sekretin is classified as "Исследования (прочее)". Oxytocin: Oxytocin is an endogenous nonapeptide hormone of the posterior pituitary. In synthetic form (Pitocin, Syntocinon) it has been approved for decades to induce and augment labour and to control postpartum uterine bleeding. Strictly separate from this is intranasal use to influence social behaviour, trust, anxiety or autism symptoms: this use is unapproved, purely experimental, and yields inconsistent and often negative results in controlled trials. Sekretin: Secretin is a 27-amino-acid hormone that regulates pancreatic bicarbonate secretion. As ChiRhoStim it is FDA-approved as a diagnostic agent (pancreatic function test, gastrinoma test, secretin-enhanced MRCP). This page contrasts both neutrally and source-based — with no usage or dosing recommendation.
- Which peptide is better supported by science, Oxytocin or Sekretin?
- The highest available evidence level is "РКИ на людях" for Oxytocin and "Исследование на людях" for Sekretin. A higher evidence level means more robust data, but says nothing about suitability for an individual. The full body of evidence is on each peptide's own page.
- What is the legal status of Oxytocin and Sekretin in Germany and the United States?
- Германия: Oxytocin — Рецептурный, Sekretin — Рецептурный. США: Oxytocin — Рецептурный, Sekretin — Рецептурный. These are factual summaries with source and review date on the individual pages.